In silico discoveries for biomedical sciences
Haagen, H. van
Citation
Haagen, H. van. (2011, September 21). In silico discoveries for biomedical sciences. Retrieved from https://hdl.handle.net/1887/17847
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
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In silico discoveries for biomedical sciences
Herman van Haagen
Promotiecommissie
Promotor prof. dr. J.T. den Dunnen LUMC
Co-promotors dr. B. Mons NBIC
dr. P.A.C. 't Hoen LUMC
dr. M.J. Schuemie EMC Rotterdam
Overige leden prof. dr. ir. M.J.T. Reinders TU Delft
prof. dr. J.N. Kok LIACS Leiden
prof. dr. F. A. H. van Harmelen VU Amsterdam
Herman van Haagen
In silico discoveries for biomedical sciences ISBN/EAN: 978-90-817676-0-6
©H. van Haagen, 2011
Cover design: Freek van Haagen
In silico discoveries for biomedical sciences
Proefschrift ter verkrijging van
de graad van Doctor aan de Universiteit van Leiden op gezag van Rector Magnificus prof. mr. P. F. van der Heijden
volgens besluit van het College van Promoties te verdedigen op woensdag 21 september 2011
klokke 11.15 uur door
Herman van Haagen geboren te Breda in 1979
Table of content
Chapter Title Page
1 Introduction 3
2 In silico knowledge and content tracking 19 3 Novel protein-protein interactions inferred
from literature context
32 4 In silico discovery and experimental validation
of new protein-protein interactions
65 5 Finding gene-disease relations using implicit
information in the scientific literature
98
6 General discussion 115
Summary 127
Samenvatting 130
Curriculum vitae 134
