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The handle http://hdl.handle.net/1887/32654 holds various files of this Leiden University dissertation.

Author: Nucifora, Gaetano

Title: Clinical applications of non-invasive imaging techniques in suspected coronary artery disease and in acute myocardial infarction

Issue Date: 2015-04-02

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CLINICAL APPLICATIONS OF NON-INVASIVE IMAGING TECHNIQUES IN SUSPECTED CORONARY ARTERY DISEASE AND IN

ACUTE MYOCARDIAL INFARCTION

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Clinical Applications of Non-invasive Imaging Techniques in Suspected Coronary Artery Disease and in Acute Myocardial Infarction.

The studies described in this thesis were performed at the Department of Cardiology of Leiden University Medical Center, Leiden, The Netherlands Cover and lay-out: Gaetano Nucifora

Print: Tipografia Tomadini, Udine, Italy ISBN: 979-12-200-0020-8

Copyright© Gaetano Nucifora, Leiden, The Netherlands. All rights reserved. No part of this book may be reproduced or transmitted, in any form or by any means, without permission of the author.

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CLINICAL APPLICATIONS OF NON-INVASIVE IMAGING TECHNIQUES IN SUSPECTED CORONARY ARTERY DISEASE AND IN ACUTE MYOCARDIAL INFARCTION

Proefschrift

Ter verkrijging van de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof. mr. C.J.J.M. Stolker, volgens besluit van

het College voor Promoties te verdedigen op 2 april 2015 klokke 16.15 uur

door

Gaetano Nucifora Geboren te Udine in 1976

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PROMOTIECOMISSIE

Promotor

Prof. Dr. Jeroen J Bax

Co-promotor

Dr. Nina Ajmone Marsan

Overige Leden

Prof. dr. Juhani Knuuti, Turku University Hospital, Turku, Finland Prof. dr. J.W. Jukema

Prof. dr. Robert J. Klautz Prof. dr. Johan H.C. Reiber Dr. Eduard R. Holman Dr. Victoria Delgado

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To Fjoralba and my parents

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Table of Contents

Chapter 1. 11

General Introduction and Outline of the Thesis PART I. Risk Stratification With MDCT

Chapter 2. 25

Coronary Artery Calcium Scoring in Cardiovascular Risk Assessment

Cardiovasc Ther 2011;29:e43-53

Chapter 3. 51

Prevalence of Coronary Artery Disease Across the Framingham Risk Categories: Coronary Artery Calcium Scoring and MSCT Coronary Angiography

J Nucl Cardiol 2009;16:368–75

Chapter 4. 69

Relation Between Framingham Risk Categories and the Presence of Functionally Relevant Coronary Lesions as Determined on Multislice Computed Tomography and Stress Testing

Am J Cardiol 2009;104:758–763

Chapter 5. 85

Prevalence of Coronary Artery Disease Assessed by Multislice Computed Tomography Coronary Angiography in Patients With Paroxysmal or Persistent Atrial Fibrillation

Circ Cardiovasc Imaging 2009;2:100-106

Chapter 6. 107

Relationship Between Obstructive Coronary Artery Disease and Abnormal Stress Testing in Patients With Paroxysmal or Persistent Atrial Fibrillation Int J Cardiovasc Imaging 2011;27:777–785

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Chapter 7. 125

Usefulness of Echocardiographic Assessment of Cardiac and Ascending Aorta Calcific Deposits to Predict Coronary Artery Calcium and Presence and Severity of Obstructive Coronary Artery Disease

Am J Cardiol 2009;103:1045–1050

Chapter 8. 141

Incremental Value of Subclinical Left Ventricular Systolic Dysfunction for the Identification of Patients With Obstructive Coronary Artery Disease Am Heart J 2010;159:148-57

PART II. Assessment of Patients With STEMI: Role of Echocardiographic Techniques

Chapter 9. 167

Real-time 3-Dimensional Echocardiography Early After Acute Myocardial Infarction: Incremental Value of Echo-Contrast for Assessment of Left Ventricular Function

Am Heart J 2009;157:882.e1-8

Chapter 10. 187

Left Ventricular Muscle and Fluid Mechanics in Acute Myocardial Infarction Am J Cardiol 2010;106:1404 –1409

Chapter 11. 205

Reduced Left Ventricular Torsion Early After Myocardial Infarction Is Related to Left Ventricular Remodeling

Circ Cardiovasc Imaging 2010;3:433-442

Chapter 12. 229

Impact of Left Ventricular Dyssynchrony Early on Left Ventricular Function After First Acute Myocardial Infarction

Am J Cardiol 2010;105:306–311

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Chapter 13. 245

Temporal Evolution of Left Ventricular Dyssynchrony After Myocardial Infarction: Relation With Changes in Left Ventricular Systolic Function Eur Heart J Cardiovasc Imaging 2012:13;1041–1046

Summary and Conclusions 261 Samenvatting en Conclusies 267 List of Publications 273

Curriculum Vitae 287 Acknowledgments 289

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