Cell adhesion signalling in acute renal failure
Qin, Y.
Citation
Qin, Y. (2011, October 18). Cell adhesion signalling in acute renal failure. Retrieved from https://hdl.handle.net/1887/17953
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
Downloaded from: https://hdl.handle.net/1887/17953
Note: To cite this publication please use the final published version (if applicable).
Cell adhesion signalling in acute renal failure
Yu Qin
Yu Qin
Cell adhesion signalling in acute renal failure Thesis, Leiden University, 2011
© Yu Qin 2011
ISBN: 978-90-8570-302-0 Cover designed by Yu Qin
Printed by Wöhrmann Print Service, Zutphen, The Netherlands
All rights reserved. No part of this thesis may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, without the prior written permission of the copyright holder.
Cell adhesion signalling in acute renal failure
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van Rector Magnificus prof. mr. P.F. van der Heijden, volgens besluit van het College voor Promoties
te verdedigen op dinsdag 18 Oktober 2011 klokke 15.00 uur
door
Yu Qin
geboren te Changzhou, P. R. China in 1981
PROMOTIECOMMISSIE
Promotor:
Co-promotor:
Overige leden:
Prof. Dr. B. van de Water
Dr. L. S. Price
Prof. Dr. D. Dietrich Prof. Dr. P. M. T. Deen Prof. Dr. M. Danhof Prof. Dr. J. Kuiper Prof. Dr. T. Hankemeier Dr. E. de Heer
LACDR, Leiden
LACDR, Leiden
University of Konstanz, Germany RUNMC, Nijmegen
LACDR, Leiden LACDR, Leiden LACDR, Leiden LUMC, Leiden
The studies presented in this thesis were performed at the Division of Toxicology of the Leiden/Amsterdam Center for Drug Research (LACDR), Leiden University, Leiden, The Netherlands.
The research described in this thesis was financially supported by the China Scholarship Council (CSC) and LACDR.
The printing of this thesis was financially supported by LACDR.
TABLE OF CONTENTS
Chapter 1
General introduction
Chapter 2
Extracellular signal-regulated kinase activation during renal
ischemia/reperfusion mediates focal adhesion dissolution and renal injury
Chapter 3
Focal adhesion kinase signalling mediates acute renal injury induced by ischemia/reperfusion
Chapter 4
Epac-Rap signalling reduces cellular stress and ischemia-induced kidney failure
Chapter 5
Cyclic AMP signalling protects proximal tubular epithelial cells from cisplatin-induced apoptosis via activation of Epac
Chapter 6
A transcriptomics analysis of ATP depletion-mediated stress responses in primary rat proximal tubular epithelial cells
Chapter 7
General discussion
Summary Samenvatting
List of abbreviations List of publications Curriculum vitae
7
37
55
79
101
125
149 161 165 169 171 173
