University of Groningen
MIF family proteins in lung diseases
Song, Shanshan
DOI:
10.33612/diss.172449812
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Publication date: 2021
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Citation for published version (APA):
Song, S. (2021). MIF family proteins in lung diseases. University of Groningen. https://doi.org/10.33612/diss.172449812
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For me, the experience of doing a PhD is like a long-distance running. The start of this race is exciting. Then I got frustration and felt tired. Fortunately, I calmed down and went forward step by step. When I look back at my PhD journey, I feel so lucky and grateful that I was never alone on the way. Therefore, I want to take this opportunity to remember this journey, more importantly, to express my gratitude.
Firstly, I would like to thank my supervisors: Prof. Barbro Melgert,Prof. Gerrit
Poelarends and Prof. Peter Olinga. Thank you not only for the opportunity to start
my PhD, but also for your patience, encouragement, and support all the way through.
Barbro, I feel so lucky to be your PhD student. In the past four and half years, we
had so many meetings and talks. These interactions shaped my mind on both life and science. As a researcher, you are highly passionate on studying reallife-related topics. What you inspired me a lot is that you bring questions from daily life into the lab, which subsequently provides you new insights into our life. Of course, involvement of daily issues in research never compromises your strictness on the quality of work. Your rigorousness on the number of repeats and statistics in preparation for my first manuscript surprised me. But I know what I learn from it will definitely benefit my career. Besides, you always motivate me to break the boundaries set by myself. My milestones like giving my first oral presentation on the international conference and writing my first manuscript would come much later without your encouragement. Most importantly, you never just simply pushed me into these new things. When I came close to stress, you were always there to help me or suggest me to have a vacation. Your considerateness and openness always make me feel safe and calm. So, I was so excited when you offered me a postdoc position. I really appreciate your trust and I believe we will have good cooperation continuously. Here, I wish you enjoy your life, your science, and the combination.
Gerrit, do you know how many times I was amazed by the broadness of your
knowledge and your critical thinking? Until now, I still can not believe that my second supervisor, whose research is focused on using the enzyme to catalyze chemistry reactions, provided me so many inspirations and valuable suggestions for my project on studying functions of MIF in lung disease. I often imagined how you can talk about “Michael addition reaction” in this minute and then start to discuss “chronic obstructive pulmonary disease” two minutes later. Of course, I know it is because of your curiosity and your constant learning. More importantly, you can balance critical
leader. And I know I can never reach your level of presenting, thinking and leading. But I am happy I at least have a direction. I wish you can keep healthy, and keep on inspiring people.
Peter, as you are my third supervisor, I know you are always there when I need help.
Thanks for your presence on these key points of my PhD progress.
Next, I thank the assessment committee members of my thesis: Prof. Jürgen
Bernhagen, Prof. Silke Meiners, and Prof. Irene Heijink. Your constructive
comments and suggestions help to improve both my thesis and my critical thinking. Here, I would like to express my special thanks to Prof. Jürgen Bernhagen. You are a pioneering expert on MIF and D-DT research and your papers gave me so many inspirations. I am so excited that you can read my thesis and be my defense opponent. I thank all current and previous colleagues of Melgert’s group. Marina de Jager, as our technician, you are always willing to help. Thank you for helping me with staining, ordering and organization. You are a nice person to talk, and to work together. Habibie and Fransien Van Dijk, I am so lucky to have you two nice and special colleagues during the last few years. Habibie, thanks for all your help, company and sharing the anxiety with me. It’s my honor to have you as my paranymph. I wish you a very successful PhD ceremony. Dear Fransien, thank you for this friendship, understanding and all your help, wish you a wonderful life with Jakko, Josefien and Roosmarijn, and hope to see you soon. Laura Florez-Sampedro, thanks for sharing protocols with me and fighting together with MIF/D-DT monsters. Sara Russo, thanks for helping me with MPI cells, wish you a great time in our group. Jelmer Vlasma, thanks for the discussion about introducing macrophages to organoids, and materials supporting.
Anienke van der Veen, Gwenda Vasse, Adhyatmika, thanks for cooperation, input
to my research and importantly for the companies and friendships. I wish you all the best in your personal life and your future career!
I would like to express my gratitude to all members of the department Molecular Pharmacology. Prof. Martina Schmidt, our captain, thanks for making our department a nice place to work at. Your humor at group meetings is “sometimes” funny, but always inspiring. Your cards and flowers really warmed my heart and cheer me up. Prof. Reinoud Gosens, many thanks for insightful discussions and great
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contributions to my project. I still remembered when I gave a presentation in GRIAC meeting, you came and gave me advice for future plans; when I came to you with manuscript revisions, you sent me a long list of your suggestion to each question. I really appreciate your effort and patience for a PhD student who is not under your supervision. Also, you always encourage academic communication and share the latest scientific information in and outside the lab actively and selflessly. All of these show me an excellent example of a scientist. Prof. Amalia Dolga, when our group just moved in, your sunshine-like smiles really made me feel welcomed and included. Your enthusiasm for research encouraged me, especially when I faced difficulties. I can imagine how difficult you faced during building up your own group abroad. Wish you a big success in the research! My sincere gratitude to our organoid team as well: Lose Kistemaker, Vick Verschut, Manon Woest, Luke van der Koog,
Chiara Ciminieri, thanks for collaborations and keeping the organoid team running
smoothly. Marina Trombetta Lima, many thanks for your selfless help. Whenever I asked you for help, you always responded positively despite your busy schedule.
Sophie Bos, thanks for helping me with everything patiently in the lab when we just
moved in. I really appreciate your time and efforts. Mellisa van der Veen, a shiny girl, thanks for introducing lab rules to me and showing me all details in the lab. You were always willing to help whenever I asked. Carolina Elzinga, thanks for all the things you took care of to keep the lab organized and functioning. Brenda Tiemens, thanks for helping us with complex paperwork, it makes our life easier. To the group members: Hoeke Baarsma, Nshunge Musheshe, Angelica Sabogal, Siti Farah
Rahmawati, Asmaa Oun, Tong Zhang, Yuequ Zhang, Pien Goldsteen, Hong Yan, Zaid Elhusseini, Tingting Chen and Margot de Looff, your presence make the
department lively. Even though we just worked together for one year, unfortunately most of the time we work at home or in different shifts. But your kindness and help supported me to integrate into a new department. Thanks for your kindness during the work, and dinners, drinks and pub quiz after the work. I wish you a great time in the department and a happy and successful research.
To all members of the department of Chemical and Pharmaceutical Biology, I would like to thank you for your help and collaboration. Prof. Frank Dekker and Prof.
Hidde Haisma, thanks for your great contribution to my project. It was a pleasant
experience to work with you. I learned much chemical knowledge from your team.
purification. You taught me step by step. I really appreciate your assistance and patience. Rita Setroikromo, thank you for a lot of talk about research and life with me and for always being willing to help. I missed your food, after COVID we should organize more Indonesian-Chinese lunch together. Jielin Zhang and Baojie Zhang, it is my fortune to meet you in Groningen. Jielin, you have a lot of life wisdom and give me selfless help just like my sister. Wish you a very successful career and a happy life. Hope to see you soon! Beojie, you are a straight and lovely girl. Thanks for your company and help when I was in a tough time. I wish you a very happy time with
Xiaodong Chen and Loui in Cambridge. Deng Chen, you have a talent for scientific
research, thanks for discussion of projects with me. Wish you and Yi Guo a wonderful time in Groningen. Bin Liu, thanks for teaching me CRISPR-Cas9 technique. Wish you and Lin Zhou a happy time in Boston. To former and present group member:
Michele, Lieuwe, Andreas, Saravanan, Saif, Eleonora, Marie, Tjie, Jane, Zainal, Joko, Putri, Abel, Yafeng, Xinyu, Siqi, Fengzhi, Magda, Olivia, Martijn, Hannah, Ali, and Siwei thanks for contributing to a great atmosphere in and outside of the lab!
I would like to thank all members of department of Pharmacoketics, Toxicology and Targeting. Gillian Nieuwemhuis-Dempsey, I really missed the talk with you. At beginning of my PhD, I was too shy to talk to people, but your understanding and humor made me relaxed. Thanks for all your support and help. Eduard Post, thank you for all your great tips in the lab, and also for taking care of my computer.
Catherina Reker-Smit, for your constant help in the lab. Dr. Leonie BelJaars, I
really appreciate your taking care of me when Barbro was sick. You explained many details of IHC staining to and gave me a Pathology book. Many thanks for your kind help and support. Prof. Anna Salvati, thanks for inviting me to your group dinner at your home in the first week of my PhD. It was a beautiful memory. Dr. Deville Sarah, an elegant lady, thanks for your kindness. You gave me a lot of help and support when I was a fresh PhD student. Really miss you. I believe you will have an excellent work at Ghent university. Additionally, to the PhD students, Roberta Bartucci, Daphne
Montizaan, Valentina Francia, Natalia Estrada Ortiz, Viktoriia Starokozhko, Hetor Garcia, Harita Yedavally and Aldy Aliyandi, many thanks for your kindness,
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I also want to thank all the participants of the Lung Pathology meeting. Prof. Wim
Timens, I still clearly remember you taught me how to understand the histology
staining during my first presentation. I was surprised by your extensive knowledge of histology. Prof. Janette Burgess, thanks for your insightful comments and suggestions in the meeting. These questions helped to sharpen my critical thinking and broaden my perspectives. I was always looking forward to your advice on my presentation.
Prof. Machteld Hylkema, I thank you for initiating our collaboration. I learned a
lot from our meetings and hope we will have more collaborations in the future. Prof.
Corry-Anke Brandsma, many thanks for your great contribution to my project. Both
the human material and your constructive revisions helped a lot in my manuscript. To
Dr. Sabine Bartel and Khosbayar Lkhagvadorj, for your nice staining protocol and
for showing me step by step. To Dr. Hataitip Tasena, Roy Woldhuis, Roderick de
Hilster, Kaj Blokland, Niek Bekker, Kingsley Nwozor, Maunick Ngassie, Mehmet Nizamoglu, Roderick the Hilster, thanks for your questions and feedback during
my presentation, your kindness, and the hallway chit-chats! Weird Kooistra thanks for your help with lung tissue distribution. Marjan Reinders-Luing, thanks for your help me to scan the staining and to cut lung tissue.
I would like to thank my officemates Rosa Kortekaas, Dan Li, Alexjandro
Marmolejo and Nada Majernikova for all the good time we shared together. How
lucky I am to have you guys in our office, I enjoyed all the chats and parties we had. Hope we could restart our monthly dinner soon. Rosa, dear girl, you are so kind, so empathetic. It is fun to talk with you. And thanks for being my paranymph. Dan, your positive attitude of life helps me to overcome the difficulties in my last period of PhD. Many thanks dear Dan. Alexjandro, you are the best, you have a talent in language and are very creative in many fields, thanks for always encouraging me. Nadka, you are the sunshine of our office, and you always bring a lot of fun to our office.
To my ex-housemates, Yizhou Wang and Yana Geng, thanks for your support and company, we shared laughs, tears, gossips, food and struggles. We are not only roommates, we are also family. Thanks for taking care of me! I wish both of you a successful career and a very happy life.
To my girls, Wenjia Wang and Xinhui Wu, for your company, sharing, understanding and support. It was hard to live abroad and finish a PhD. But luckily we have each other, we drink together, laugh together and cried together. I am so proud that two of
To my Chinses friends: Keni Yang, Yehan Tao, Chao Guo, GuangCai Xu, Fangyuan
Cao, Haigen Fu, Xiaoxuan Zhang, Jingyao Li, Binquan Zhang, Hao Guo, Yu Tian, Jingjing Deng, Yuanze Wang, we had countless trips and parties. It will be
unforgettable times in my life. I wish you all the best. Chao Wang, Xin Li, Qiang
Zheng, Zefeng Wang, Ruixue Xu, Bidong Zhang, Chunlong Zhao, Xiaobo Tian, Mei Li, I met you at the near end of my PhD. Thanks for the fun time! I will not forget
the cheerful time we spent together. Wish you have a great time in Groningen and have a wonderful PhD journey!
Last but not least, I would like to thank my family members and my fiancé. 亲爱的 爹爹，我是您最疼爱的小孙女，您永远是护着我支持我的那个人，小时候调 皮犯错误或者考试没考好，您一遍遍鼓励帮我给妈妈说情；长大了谈恋爱失 恋，您会一边替我难过一边跟我说什么是生活。有您在我真的不怕。我现在 长大了，想带您看世界，可是，这世上有太多无法弥补的遗憾。孙女永远永 远想念您！爸爸妈妈，我明白尽管你们对我有着无限的不舍，你们还是支持 我出国读书；尽管你们有着无尽的挂念，为了让我安心学习你们从未表露； 尽管你们对我有远大的期许，但是你们只让我脚踏实地从未催促。十八岁 时，你们对我说，你们给不我荣华富贵，我的一生需要自己努力。其实，爸 爸妈妈你们已经给了我你们最好的全部，弥足珍贵，我将受益一生。我也想 念你们，我会好好努力，早日回来！樟平，谢谢你来到我身边。和你有很多 很多的话说，你可以理解我，和你聊天无论是课题还是生活还是八卦都可以 说不完。和你也可以安安静静不说话，一个眼神就明白彼此的心意。虽然我 们的相遇有点迟，但是为了这份美好，我觉得这些等待是值得的。对未来的 期许我不说，让我们一起携手走过慢慢体味！
