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Cover Page

The handle http://hdl.handle.net/1887/36056 holds various files of this Leiden University dissertation

Author: Bertini, Matteo

Title: Left ventricular mechanics in advanced heart failure patients

Issue Date: 2015-11-03

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Left ventricular mechanics in advanced heart failure patients

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Left ventricular mechanics in advanced heart failure patients

The studies described in this thesis were performed at the Department of Cardiology of Leiden University Medical Center, Leiden, The Netherlands

Cover and lay-out: Matteo Bertini

Design and printing: Optima Grafische Communicatie, Rotterdam, The Netherlands ISBN: 978-94-6169-769-1

Copyright © Matteo Bertini, Leiden, The Netherlands. All rights reserved. No part of this book may be reproduced or transmitted, in any form or by any means, without permission of the author.

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Left ventricular mechanics in advanced heart failure patients

Proefschrift

Ter verkrijging van de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof. mr. C.J.J.M. Stolker, volgens besluit van het College voor

Promoties te verdedigen op 3 november 2015 klokke 16.15 uur

door Matteo Bertini

geboren te Forlimpopoli (FC), Italy in 1976

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ProMotiecoMissie

Promotor

Prof. Dr. Jeroen J Bax co-promotor Dr. Victoria Delgado overige Leden

Prof. Dr. Cristophe Leclercq, University of Rennes, France.

Prof. Dr. J.W. Jukema Prof. Dr. Martin J Schalij Prof. dr. Robert J. Klautz Dr. Harriette Verwey Dr. Nina Ajmone Marsan

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To Anna Chiara and Samuele

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taBLe of contents

chapter 1: General introduction and outline thesis 9

Part i: Heart failure

chapter 2: Role of left ventricular twist mechanics in the assessment of cardiac dyssynchrony in heart failure. JACC Cardiovasc Imaging. 2009 Dec;

2(12): 1425-35.

19

chapter 3: Left ventricular rotational mechanics in acute myocardial infarction and in chronic (ischemic and nonischemic) heart failure patients.

Am J Cardiol. 2009 Jun 1; 103(11): 1506-12.

39

chapter 4: Effects of cardiac resynchronization therapy on left ventricular twist. J Am Coll Cardiol. 2009 Sep 29; 54(14): 1317-25.

53

chapter 5: Effect of cardiac resynchronization therapy on subendo- and subepicardial left ventricular twist mechanics and relation to favorable outcome. Am J Cardiol. 2010 Sep 1; 106(5): 682-7.

73

chapter 6: Prediction of cardiac resynchronization therapy response: value of calibrated integrated backscatter imaging. Circ Cardiovasc Imaging. 2010 Jan; 3(1): 86-93.

87

chapter 7: Why, how and when do we need to optimize the setting of cardiac resynchronization therapy? Europace 2009; 11: v46-v57

107

Part ii: Prognostic evaluation

chapter 8: Impact of clinical and echocardiographic response to cardiac resynchronization therapy on long-term survival. Eur Heart J Cardiovasc Imaging. 2013; 14(8): 774-81

129

chapter 9: Longitudinal mechanics of the periinfarct zone and ventricular tachycardia inducibility in patients with chronic ischemic cardiomyopathy.

Am Heart J. 2010 Oct; 160(4): 729-36.

145

chapter 10: Global longitudinal strain predicts long-term survival in patients with chornic ischemic cardiomyopathy. Circ Cardiovasc Imaging. 2012; 5(3):

383-91

161

chapter 11: Prediction of atrial fibrillation in patients with an implantable cardioverter-defibrillator and heart failure. Eur J Heart Fail. 2010 Oct; 12(10):

1101-10.

181

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8 Table of Contents

chapter 12: summary and conclusions 203

samenvatting en conclusie 207

List of publications 209

curriculum vitae 221

acknowledgements 223

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