Cover Page The handle

Cover Page

The handle

http://hdl.handle.net/1887/137968

holds various files of this Leiden

University dissertation.

Author:

Hamming, A.M.

Title:

Spreading depolarizations, migraine and ischemia: A detrimental triangle in

subarachnoid hemorrhage and ischemic stroke?

Stellingen behorend bij het proefschrift getiteld:

Spreading depolarizations, migraine and ischemia

hemorrhage in rats. (This thesis)

2. Valproate treatment may reduce brain lesion growth after subarachnoid hemorrhage. (This thesis) The most likely explanation for this finding is inhibition of spreading depolarizations.

3. MRI enables simultaneous measurement of cellular and hemodynamic responses to spreading depolarizations. (This thesis)

4. Patients with subarachnoid hemorrhage who use spreading depolarization-inhibiting drugs may have less delayed cerebral ischemia, but may not necessarily have a better outcome. (This thesis)

5. Understanding the adverse effects of spreading depolarization-inhibiting medication may be not just an interesting digression, but a necessary next step before focusing on the translation of our findings to clinical practice. (This thesis)

6. In subarachnoid hemorrhage, spreading depolarizations with prolonged depolarization are indicators of impending and progressive neuronal damage in the human brain. (Dreier, Brain 2006) – And possibly a contributing factor.

7. For treatment of diseases in which spreading depolarization (SD) is involved, SD-inhibitors will probably be most effective in prophylaxis rather than as abortive treatment. (Ayata, Cephalalgia 2009) – Yet a pretreatment period of at most a few days is required.

8. Therapies that target spreading depolarization or the subsequent inverse hemodynamic response may potentially limit brain damage after subarachnoid hemorrhage. (Dreier, Nat. Med. 2011) – These therapies have a better chance of being effective, when specifically targeting the mechanisms involved in spreading depolarization.

9. Spreading depolarizations are the electrophysiological correlate for migraine aura. (Hadjikhani, Proc. Natl. Acad. 2001) – This might be their most benign clinical presentation.

10. Sometimes I ponder for hours and don’t get anything written. Other times I achieve the exactly the same in five minutes. (Finkers) – Imagine what I didn’t get written in the years this thesis took.

11. There is a life after the deadline. (Gard to Hamming) – Life begins after the deadline.

12. For a better karma, animal researchers should compensate the sacrifice of animals with a vegetarian diet.

Arend Hamming Leiden, 12 November 2020