Population pharmacokinetics of antibiotics to prevent group B streptococcal disease: from mother to neonate Muller, A.E.

Both amoxicillin and clavulanic acid are in part metabolized, but the absence of pharmacokinetic drug interaction in this study indicates that the individual drugs do not influence

In the period between February 7, 2005 and February 28, 2007, all women who needed antibiotic treatment with amoxicillin or amoxicillin/clavulanic acid (Augmentin ® or

Figure 2: Percent of time the unbound fraction of amoxicillin remained above the MIC (%fT>MIC) as a function of the MIC for two dosing intervals, 4 hours (figure 2a) and 6

The area under the curve (AUC) was calculated using the trapezoid rule for the first, 2 gram, amoxicillin administration in the case-patient, as well as for the

License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden Downloaded from: https://hdl.handle.net/1887/13469.

The mean pharmacokinetic estimates of the final model derived from the PK analysis in NONMEM were used in Berkeley Madonna (version 8.3.5, Berkeley Madonna Inc, University

We investigated the pharmacokinetics of penicillin G and the adequacy of the dosing regimen in very premature neonates on the third day of life to allow us to construct a

Finally, a pharmacokinetic model should be developed based on pharmacokinetic parameter estimates of both the mother and fetus, the inter-individual variability as well as data on