Cover Page
The following handle holds various files of this Leiden University dissertation:
http://hdl.handle.net/1887/74006
Author: Esbroeck, A.C.M. van
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Activity-based protein profiling
in drug discovery
PROEFSCHRIFT
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties te verdedigen op dinsdag 28 mei 2019
klokke 13:45 uur
door
Annelot Clementine Mathilda van Esbroeck
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Promotiecommissie
Promotoren Prof. dr. M. van der Stelt, Leiden University Prof. dr. J. Brouwer, Leiden University Overige leden Prof. dr. H.S. Overkleeft, Leiden University
Prof. dr. H. Spaink, Leiden University Prof. dr. T. Hankemeier, Leiden University
Prof. dr. S. Kushner, Erasmus Medical Centre Rotterdam Mw. dr. J. Meijerink, University of Wageningen
ISBN: 978-94-028-1497-2
Printed by: Proefschriften.net
Cover design: Van Esbroeck Weevers
Quote page 3: Isaac Newton’s letter to Robert Hooke, 5 February 1675
Available via the Historical Society of Pennsylvania
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“If I have seen further, it is by standing on the shoulders of giants.”
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Chapter 1
7
General introduction: Activity-based protein profiling in drug discovery
Chapter 2
19
Activity-based protein profiling of the human ischemic heart
Chapter 3
37
Applications of activity-based protein profiling in developing zebrafish
Chapter 4
59
Activity-based protein profiling reveals off-target proteins of FAAH inhibitor BIA 10-2474
Chapter 5
83
Identification of ABHD6 as a diacylglycerol lipase
Chapter 6
103
Summary & future prospects
