The role of p53.S389 phosphorylation in DNA damage
response pathways and tumorigenesis
Bruins, W.
Citation
Bruins, W. (2007, October 24). The role of p53.S389 phosphorylation in DNA damage response pathways and tumorigenesis. Department Toxicogenetics, Medicine / Leiden University Medical Center (LUMC), Leiden University.
Retrieved from https://hdl.handle.net/1887/12389
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
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Contents
Chapter 1 General introduction
Chapter 2 Increased sensitivity to UV radiation in mice with a p53 point mutation at Ser389
Moll.Cell.Biol. (2004) Oct;24(20):8884-8894
Chapter 3 Absence of Ser389 phosphorylation in p53 affects the basal gene-expression level of many p53-dependent genes and alters the biphasic response to UV exposure in MEFs
Submitted for publication
Chapter 4 Lack of p53.S389 phosphorylation predisposes mice to develop 2-acetylaminofluorene-induced bladder tumors but not ionizing radiation-induced lymphomas
Cancer Res.(2005) May;65(9):3610-3616
Chapter 5 Delayed expression of apoptotic and cell cycle control genes in carcinogen-exposed bladders of mice lacking p53.S389 phosphorylation
Carcinogenesis (2007) Aug; 28(8):1814-1823
Chapter 6 Phosphorylation of p53 at serine 389 is compound-specific and possibly initiated by stalled RNA polymerases
Chapter 7 Summary and concluding remarks Samenvatting
Abbreviations Curriculum Vitae List of publications Color figures
11 45
67
93
111
141
157 173177 178179 180
