Epidemiology and pathogenetic mechanisms of polymorphic light eruption
Janssens, A.S.
Citation
Janssens, A. S. (2008, January 17). Epidemiology and pathogenetic mechanisms of polymorphic light eruption. Retrieved from https://hdl.handle.net/1887/12576
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
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EPIDEMIOLOGY AND
PATHOGENETIC MECHANISMS OF POLYMORPHIC LIGHT
ERUPTION
The research described in this thesis was done at the department of dermatology, Leids Universitair Medisch Centrum, Leiden.
The studies described in this thesis were financially supported by the European Framework V program (project grant no. QLK4-CT01-0015).
Publication of this thesis was financially supported by Astellas Pharma Netherlands, Fagron BV, Galderma Nederland, Leo Pharma BV, Mölnlycke Health Care BV, Schering-Plough BV, Serono Benelux BV, Wyeth Pharmaceuticals BV, Firma Oldekamp, GlaxoSmithKline, Vichy, Louis Widmer, Beiersdorf and LaRoche-Posay.
Epidemiology and pathogenetic mechanisms of polymorphic light eruption Thesis, Rijksuniversiteit Leiden, the Netherlands
Copyright © 2008, Artiena Soe Janssens, the Netherlands
No part of this thesis may be reproduced, stored or transmitted without prior permission of the author.
ISBN 978-90-8891-0258
EPIDEMIOLOGY AND
PATHOGENETIC MECHANISMS OF POLYMORPHIC LIGHT
ERUPTION
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van de Rector Magnificus
prof. mr. P. F. van der Heijden,
volgens het besluit van het College voor Promoties te verdedigen op donderdag 17 januari 2008
klokke 15:00 uur
door
Artiena Soe Janssens
geboren te Seoul, Zuid-Korea in 1973
Met opmaak: Engels (Groot-Brittannië)
Met opmaak: Nederlands (standaard)
Met opmaak: Nederlands (standaard)
Promotiecommissie
Promotor prof. dr. R. Willemze
Co-promotores dr. S. Pavel dr. F. R. de Gruijl
Referent prof. dr. R. Roelandts (Katholieke Universiteit Leuven, België) Overige leden prof. dr. F. H. J. Claas
prof. dr. R. G. J. Westendorp
Voor Sarah
List of abbreviations
CD1a cluster of differentiation 1a
CDLE cutaneous discoid lupus erythematosus ELISA enzyme-linked immuno sorbent assay
ICAM-1 intercellular adhesion molecule-1 IL interleukin
IL-1Ra interleukin-1 receptor antagonist LC Langerhans cell
MCP-1 monocyte chemotacting protein-1 MED minimal erythema dose
MIP-1 macrophage inflammatory protein-1
PBS phosphate buffered saline PLE polymorphic light eruption
PLESS polymorphic light eruption severity score
RANTES regulated on activation, normal T expressed and secreted
SLE systemic lupus erythematosus
SCLE subacute cutaneous lupus erythematosus SSR solar simulated radiation
TNF-D tumor necrosis factor-alfa
UV ultraviolet UVA ultraviolet A UVB ultraviolet B
Contents
Chapter 1 Introduction
Chapter 2
Lifetime prevalence and characteristics of the ‘sun-allergy’ polymorphic light eruption in Europe
Chapter 3
UVB-induced leukocyte trafficking in the epidermis of photosensitive lupus erythematosus patients: normal depletion of Langerhans cells
Chapter 4
Normalised UV induction of Langerhans cell depletion and neutrophil infiltrates after artificial UVB hardening of patients with polymorphic light eruption
Chapter 5
Reduced IL1-Ra/IL-1 ratio in UVB-exposed skin of patients with polymorphic light eruption
Chapter 6
Susceptibility to UVA and UVB provocation does not correlate with disease severity of polymorphic light eruption
Chapter 7
Summary and discussion
Appendices
Nederlandse samenvatting Curriculum vitae
Publicaties Dankwoord
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