Prolactinomas : clinical studies
Kars, M.
Citation
Kars, M. (2008, September 10). Prolactinomas : clinical studies. Retrieved from https://hdl.handle.net/1887/13092
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden Downloaded from: https://hdl.handle.net/1887/13092
Note: To cite this publication please use the final published version (if applicable).
Prolactinomas
CLINICAL STUDIES
Marleen Kars
ISBN 978-90-8559-376-8
Publication of this thesis was fi nancially supported by Ferring, Ipsen, Merck Sharp & Dohme, Novartis Oncology, Novo Nordisk, Pfi zer, Sanofi -Aventis, Servier, Will-Pharma.
Cover photo: Andrew Beierle
Cover design: Maarten Houwer and Mieke Kars
Lay-out and print: Optima Grafi sche Communicatie, Rotterdam
© 2008 M. Kars
All rights reserved. No part of this thesis may be reproduced or transmitted in any form, by any means, electronic or mechanical, without the prior written permission of the author, or where appropriate, of the publisher of the articles.
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PROLACTINOMAS
CLINICAL STUDIES
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van Rector Magnifi cus prof.mr. P.F. van der Heijden,
volgens besluit van het College voor Promoties
te verdedigen op woensdag 10 september 2008
klokke 15.00 uur
door
Marleen Kars
geboren te Oudewater
in 1975
PROMOTIECOMMISSIE
Promotores: Prof.dr. J.A. Romijn Prof.dr. J.W.A. Smit
Copromotor: Dr. A.M. Pereira Arias
Referent: Prof.dr. E. Fliers, Academisch Medisch Centrum, Amsterdam
Overige leden: Prof.dr. H. Pijl Prof.dr. J.H. Bolk
Prof.dr. M.H.H. Kramer, Vrije Universiteit Medisch Centrum, Amsterdam
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CONTENTS
Chapter 1. Introduction 7
Chapter 2. Long-term outcome of patients with macroprolactinomas initially treated with dopamine agonists. Submitted
29
Chapter 3. Aortic valve calcifi cation and mild tricuspid regurgitation, but no clinical heart disease after 8 years of dopamine agonist therapy for prolactinoma. J Clin Endocrinol Metab, in press
43
Chapter 4. Quality of life is decreased in female patients treated for micropro- lactinoma. Eur J Endocrinol 2007;157:133-139
59
Chapter 5. Disease-specifi c impairments in quality of life during long-term follow-up of patients with diff erent pituitary adenomas. Clin Endo- crinol (Oxf), doi:10.1111/j.1365-2265.2008.03288
73
Chapter 6. Malignant prolactinoma: case report and review of the literature.
Eur J Endocrinol 2006;155:523-534
91
Chapter 7. General discussion and conclusions 109
Chapter 8. Samenvatting 127
Nawoord 145
Curriculum Vitae 149
Publicaties 151
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