Citation
Neijssen, J. J. (2008, February 6). The fate of intracellular peptides and MHC class I antigen presentation. Retrieved from https://hdl.handle.net/1887/12591
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The Fate of Intracellular Peptides and MHC Class I Antigen Presentation
J.J. Neijssen
The Fate of Intracellular Peptides and MHC Class I Antigen Presentation
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van de Rector Magnificus prof.mr. P.F. van der Heijden, volgens besluit van het College voor Promoties
te verdedigen op woensdag 6 februari 2008 klokke 15.00 uur
door
Johannes Jacobus Neijssen geboren te Weert
in 1978
Referent: Prof. Dr. T. Schumacher Overige leden: Prof. Dr. J. Borst
Universiteit van Amsterdam
Prof. Dr. C. Melief Prof. Dr. W. Moolenaar
Dr. F. Ossendorp
Dr. E.A.J. Reits
Universiteit van Amsterdam
© 2008 J.J. Neijssen
Cover: Johan Strumane |32 charcoal on paper | 2007 |www.johanstrumane.be
The research described in this thesis was performed at the division of Tumor Biology at The Netherlands Cancer Institute (Antonie van Leeuwenhoek Ziekenhuis, NKI/AVL) under the supervision of Prof. Dr. J. Neefjes and supported by grants of the Dutch Can- cer Society (KWF) and the Netherland Organization for Scientific Research (NWO).
Financial support for the publication of this thesis was provided by:
Dutch Cancer Society (KWF), Nederlandse Vereniging voor Microscopie, Genmab B.V.
Table of contents
Introduction
Chapter 1 MHC class I alleles and their exploration of the antigen-
processing machinery.
Chapter 2 Gap junction-mediated intercellular communication in the immune system.
Peptidase activity in living cells
Chapter 3 Peptide diffusion, protection, and degradation in nuclear and cytoplasmic compartments before antigen presenta- tion by MHC class I.
Chapter 4 A major role for TPPII in trimming proteasomal degradtion- products for MHC class I antigen presentation.
Chapter 5 Cutting edge: HLA-B27 acquires many N-terminal dibasic peptides: Coupling cytosolic peptide stability to antigen presentation.
Intercellular peptide transfer through gap junctions
Chapter 6 Cross-presentation by intercellular peptide transfer through gap junctions.
Chapter 7 Direct antigen presenatation and gap junction mediated cross-presentation during apoptosis.
Summary
Nederlandse samenvatting List of Publications
Curriculum vitae Color figures
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