Myocardial triglycerides : magnetic resonance spectroscopy in health and diabetes
Hammer, S.
Citation
Hammer, S. (2008, November 20). Myocardial triglycerides : magnetic resonance spectroscopy in health and diabetes. Retrieved from
https://hdl.handle.net/1887/13266
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
Downloaded from: https://hdl.handle.net/1887/13266
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Myocardial Triglycerides
Magnetic Resonance Spectroscopy
in Health and Diabetes
Cover Design: Geert Gratama.
Printed by: Optima Grafische Communicatie, Rotterdam.
ISBN: 978-90-8559-409-3.
© 2008, Sebastiaan Hammer, Leiden, The Netherlands. All rights reserved. No part of this thesis may be reproduced or transmitted in any form, by any means, without prior written permission of the author.
Myocardial Triglycerides
Magnetic Resonance Spectroscopy in Health and Diabetes
proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van de Rector Magnificus prof. mr. P.F. van der Heijden,
volgens besluit van het College voor Promoties te verdedigen op donderdag 20 november 2008
klokke 15.00 uur door
Sebastiaan Hammer geboren te Utrecht
in 1981
PromotiecommiSSie
Promotores
Prof. Dr. J.W.A. Smit Prof. Dr. J.A. Romijn Prof. Dr. A. de RoosCo-promotor
Dr. H.J LambReferent
Prof. C.B. Higgins, M.D., Radiology, University of California, San Francisco, USA
Overige commissieleden
Prof. Dr. H. Pijl Prof. Dr. J.H. Bolk Prof. Dr. S.E. Papapoulos Prof. Dr. Ir. L.M. HavekesFinancial support by the Netherlands Heart Foundation and the Dutch Diabetes Foundation for the publication of this thesis is gratefully acknowledged.
Additional financial support is provided by The J.E. Jurriaanse Foundation, Foundation Imago (Oegstgeest), Foundation of Image Processing, Philips BV, Astra Zeneca BV, GlaxoSmithKline BV, Medis medical imaging systems BV, Bristol-Myers-Squibb BV, Merck Sharp & Dohme BV, Solvay Pharmaceuticals BV, Guerbet Nederland BV, Sanofi-Aventis BV and Novo Nordisk BV.
Voor mijn ouders
contents
1. General introduction 9
Part i: HealtHy VolunteerS
2. Metabolic imaging of myocardial triglyceride content: reproducibility of
1H magnetic resonance spectroscopy with respiratory navigator gating in volunteers
Radiology 2007; 245(1):251-257
27
3. Short-term caloric restriction induces accumulation of myocardial triglycerides and decreases left ventricular diastolic function in healthy subjects
Diabetes 2007; 56(12):2849-2853
41
4. Progressive caloric restriction induces dose-dependent changes in myocardial triglyceride content and diastolic function in healthy men Journal of Clinical Endocrinology and Metabolism 2008; 93(2):497-503
55
5. Effects of short-term high-fat, high-energy diet on hepatic and myocardial triglyceride content in healthy men
Journal of Clinical Endocrinology and Metabolism 2008; 93(7):2702-2708
69
Part ii: DiabeteS mellituS
6. Short-term flexibility of myocardial triglycerides and diastolic function in patients with type 2 diabetes mellitus
American Journal of Physiology - Endocrinology and Metabolism 2008;
295(3):E714-E718
87
7. Prolonged caloric restriction in obese patients with type 2 diabetes mellitus decreases myocardial triglyceride content and improves myocardial function Journal of the American College of Cardiology 2008; 52(12):1006-1012
101
8. Short-term hyperglycemic dysregulation in patients with type 1 diabetes mellitus does not change myocardial triglyceride content or myocardial function
Adapted from Diabetes Care 2008; 31(8):1613-1614
115
8
Contents
9. General discussion 127
10. Summary / Samenvatting 141
List of publications 151
Nawoord 155
Curriculum Vitae 157
