Using survival data in gene mapping : using survival data in genetic linkage and family-based association analysis

5 Weighted statistics for aggregation and linkage analysis of human longevity in selected families: The Leiden Longevity Study 59 5.1

For linkage analysis, we derive a new NPL score statistic from a shared gamma frailty model, which is similar in spirit to the score test derived in Chapter 2. We apply the methods

In order to take into account residual correlation Li and Zhong (2002) proposed an additive gamma-frailty model where the frailty is decomposed into the sum of the linkage effect and

Results: In order to investigate how age at onset of sibs and their parents af- fect the information for linkage analysis the weight functions were studied for rare and common

We propose two score tests, one derived from a gamma frailty model with pairwise likelihood and one derived from a log-normal frailty model with approximated likelihood around the

We propose a weighted statistic for aggregation analysis which tests for a relationship between a family history of excessive survival of the sibships of the long lived pairs and

In the same spirit, we propose a new class of statistics for genetic linkage analysis where the positive family-history (defined as the ungenotyped affected relatives) is included

We used these age at onset NPL methods to analyze linkage data from breast cancer families (Chapter 2 and Chapter 3), life-span (Chapter 3), the time to the first of three events: