Premanifest Huntington's disease : a study of early biomarkers
Jurgens, C.K.
Citation
Jurgens, C. K. (2011, February 1). Premanifest Huntington's disease : a study of early biomarkers. Retrieved from https://hdl.handle.net/1887/16439
Version: Corrected Publisher’s Version
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Premanifest Huntington’s Disease
Caroline Jurgens
A study of early biomarkers
Financial support for the publication of this thesis was kindly provided by the Dutch Huntington Association and the Bronovo Research Fund
PhD Thesis, Leiden University Medical Center, Leiden 2011 ISBN: 978-90-5335-366-0
© 2010, C.K. Jurgens, Den Haag
Design: Nelleke Gerlsma
Printed by: Ridderprint B.V. Ridderkerk
All rights reserved. No part of this book may be reproduced or transmitted in any from or by any means without permission of the copyright owner.
Premanifest Huntington’s Disease
A study of early biomarkers
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr. P.F. van der Heijden,
volgens besluit van het College voor Promoties te verdedigen op dinsdag 1 februari 2011
klokke 15.00 uur door
Caroline Kristien Jurgens
geboren te Winschoten in 1977
Promotiecommissie Promotores:
Prof.dr. R.A.C. Roos Prof.dr. H.A.M. Middelkoop
Co-promotor:
Dr. M.N.W. Witjes-Ané
Overige leden:
Prof.dr. A. Tibben Prof.dr. M.H. Breuning
Prof.dr. K.N. Leenders, Universitair Medisch Centrum Groningen
We zullen doorgaan, telkens als we stilstaan, om weer door te gaan (Ramses Shaffy)
Voor papa en mama
Chapter 1 9
General introduction
Chapter 2 19
Basal ganglia volume and clinical correlates in preclinical Huntington’s disease
Chapter 3 33
Magnetisation Transfer Imaging in premanifest Huntington’s disease
Chapter 4 47
MRI T2 Hypointensities in basal ganglia of premanifest Huntington’s disease
Chapter 5 61
Memory activation reveals abnormal EEG in preclinical Huntington’s disease
Chapter 6 73
Basal ganglia volume is strongly related to P3 event-related potential in premanifest Huntington’s disease
contents
Chapter 7 89
Decreased performances on psychomotor tasks in HD premanifest carriers are due to subtle changes in both motor and cognitive functioning
Chapter 8 103
Seven-year clinical follow-up study of premanifest carriers for Huntington’s disease
Chapter 9 121
Discussion and future perspectives
