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The handle # http://hdl.handle.net/1887/46804 holds various files of this Leiden University dissertation.

Author: Kerbert, A.J.C.

Title: Risk stratification in cirrhosis and acute-on-chronic liver failure : exploration of invasive and non-invasive prognostic markers

Issue Date: 2017-03-15

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RISK STRATIFICATION IN CIRRHOSIS AND ACUTE-ON-CHRONIC LIVER FAILURE Exploration of invasive and non-invasive prognostic markers

Annarein J.C. Kerbert

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Copyright © 2017, J.C. Kerbert, the Hague, the Netherlands

All rights reserved. No part of this thesis may be reproduced or transmitted in any form or by any means without prior written permission of the author.

Financial support for the publication of this thesis was kindly provided by B.R.A.H.M.S. GmbH, Dutch Society of Hepatology (NVH), Gilead Sciences Netherlands B.V. and Norgine B.V.

The research described in this thesis was financially supported by a grant from the Leiden University Medical Center and Studiefonds Ketel 1.

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RISK STRATIFICATION IN CIRRHOSIS AND ACUTE-ON-CHRONIC LIVER FAILURE Exploration of invasive and non-invasive prognostic markers

PROEFSCHRIFT

ter verkrijging van de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof. mr. C.J.J.M. Stolker,

volgens besluit van het College voor Promoties te verdedigen op woensdag 15 maart 2017

klokke 11.15 uur

door

Annarein J.C. Kerbert

geboren te Enschede in 1991

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Leden promotiecommissie Prof. dr. A.J. Rabelink Mw. dr. M.S. Arbous Dr. R.A. Veenendaal

Prof. dr. H.J. Metselaar, Erasmus Medisch Centrum, Rotterdam Prof. dr. R. Jalan, Royal Free Hospital, London, United Kingdom

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Chapter 3 41 Copeptin is an independent prognostic factor for transplant-free survival in cirrhosis

Liver International 2016;36:530-537.

Chapter 4 59 Plasma copeptin as a biomarker of disease progression and prognosis in cirrhosis

Journal of Hepatology 2016;65;914-920.

Chapter 5 79 Copeptin in patients with acute decompensation of liver cirrhosis: relationship with acute-on-chronic liver failure and survival

In revision

Chapter 6 99 Impact of genetic variation in the vasopressin 1a receptor on the development of organ failure in patients with acute

decompensation of liver cirrhosis or acute-on-chronic liver failure European Journal of Gastroenterology & Hepatology 2016; in press.

Chapter 7 109 Hemodynamic response to primary prophylactic therapy with non-selective beta-blockers is related to a reduction of first variceal bleeding risk in liver cirrhosis: a meta-analysis

European Journal of Gastroenterology & Hepatology 2016; in press.

Chapter 8 129 Hepatic encephalopathy is an independent risk factor for mortality at the liver transplant waiting list: a propensity score analysis

Submitted

Chapter 9 145 General discussion and future perspectives

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Chapter 10 167 Nederlandse samenvatting

Chapter 11 177 List of publications List of abbreviations Curriculum Vitae

Dankwoord/ acknowledgements

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