Automated morphometry of transgenic mouse brains in MR images
Scheenstra, A.E.H.
Citation
Scheenstra, A. E. H. (2011, March 24). Automated morphometry of transgenic mouse brains in MR images. Retrieved from https://hdl.handle.net/1887/16649
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
Downloaded from: https://hdl.handle.net/1887/16649
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Propositions
1. A mouse brain atlas provides all the a priori knowledge that is required for mouse brain morphometry. This Thesis
2. The 3D Moore-Rayleigh test can be used in deformation-based morphometry to locally detect the inter-group variation between two groups of mice and still provides sufficient power for the multiple-test correction. This Thesis
3. The 3D Moore-Rayleigh test gives an equal performance as permutation testing and is faster when it is applied for testing group differences with deformation-based morphometry.
This Thesis
4. Conclusions made for separate voxels should only be generalized to the whole brain if all possible sources of error are retrospectively excluded. This Thesis
5. Characterization using deformation-based morphometry can be global, pertaining to the entire field as a single observation, or can proceed on a voxel-by-voxel basis to make inferences about regionally specific positional differences. Ashburner and Friston, NeuroImage 11:805-21 (2000)
6. Our knowledge of the brain is increasing in leaps and bounds. Whether the mind can ever finally know itself, or whether it will stay a step ahead of its pursuer, like the tortoise pursued by the Achilles in Zeno’s paradox, remains a question for the philosophers.
A.P. Holmes PhD-thesis
7. A good segmentation result is in the eye of the beholder.
8. The accuracy of an image processing algorithm is upper bound by the sum of the possible errors and uncertainties of all algorithms in the image processing pipeline.
9. Social media owe their rapid growth to those who think others are interested in their amazing lives and those who want others to believe they have fascinating lives.
10. For what do we live, but to make sport for our neighbours, and laugh at them in our turn?
Mr. Bennet in Pride and Prejudice, Jane Austen 11. The unexamined life is not worth living. Socrates
Automated morphometry of transgenic mouse brains in MR images Alize Scheenstra
