Familial colorectal cancer, omics and all that jazz....
Mendes Cardoso Vaz, J.R.
Citation
Mendes Cardoso Vaz, J. R. (2007, February 14). Familial colorectal cancer,
omics and all that jazz.. Retrieved from https://hdl.handle.net/1887/9922
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral
thesis in the Institutional Repository of the University
of Leiden
Downloaded from: https://hdl.handle.net/1887/9922
Note: To cite this publication please use the final published version (if
applicable).
Stellingen
1- Pre-malignant samples of the colorectum already hold global alterations in their genetic profiles potentially relevant for tumor progression. (this thesis)
2- The genetic heterogeneity of colorectal tumors is high and it may be a consequence of subtle patient-specific genetic features combined with specific lifestyles. (this thesis) 3- The detection of a higher incidence of aneuploid changes among MAP compared to FAP
polyps tells us that loss of APC function may be necessary but not sufficient to trigger full-blown CIN in adenomas. Thus, somatic mutations targeting genes that act synergistically with APC in triggering CIN are probably required. (this thesis)
4- Expression and genomic profiling-based analysis of FAP and MAP hereditary adenomas is not enough to define mutation-specific molecular signatures. (this thesis)
5- The detection of frequent and unambiguous overall associations between loss/gain of gene expression and loss/gain of genomic regions within the same FAP or MAP adenoma sample using an integrated analysis of both copy number and gene expression microarray data can be hampered by the small effect sizes of the changes, the heterogeneity of the samples and the high signal-to-noise ratio in the analyzed array data. (this thesis)
6- Omics technologies must further adopt and develop uniform experimental and analytical strategies to prevent tumor data heterogeneity due to confounder factors which misguided the optimal utilization of the available profiling data. (this thesis)
7- Cross-species comparative analysis of the overall detected genomic alterations allowed the identification of a subset of conserved loci in mouse and human adenomas, indicating that, during intestinal tumor development, the genetic mechanisms and the underlying functional defects are conserved across species. (this thesis)
8- Statistics is the one branch of mathematics that everybody should be able to grasp - and all biologists should be required to do so. Gregory A Petsko, ”Do the math긔 in Genome Biology 2006, 7:119
9- If you obey all the rules you miss all the fun. Katherine Hepburn
10- Labor omnia vincit improbus.(Stubborn labor conquers everything). Vergilius, in Georgica I 145
11- As a scientist, a mother and a human being, I must be able to change a diaper, plan an invasion, butcher a hog, command a ship, design a building, write a sonnet, balance accounts, build a wall, set a bone, comfort the dying, take orders, give orders, cooperate, act alone, solve problems, analyze a new problem, pitch manure, program a computer, cook a tasty meal, fight efficiently, die gallantly. Specialization is for insects.
Adapted from Robert A. Heinlein, in Time Enough For Love
Joana Cardoso, 14 Februari 2007
