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Neuroendocrine perturbations in human obesity Kok, P.

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Citation

Kok, P. (2006, April 3). Neuroendocrine perturbations in human obesity. Retrieved from

https://hdl.handle.net/1887/4353

Version:

Corrected Publisher’s Version

License:

Licence agreement concerning inclusion of doctoral thesis in the

Institutional Repository of the University of Leiden

Downloaded from:

https://hdl.handle.net/1887/4353

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A d itio n a l fi n a n c ia l su p p o rt b y :

L illy Ne d e rla n d BV

P fi z e r BV

P e rk in E lm e r Ne d e rla n d B.V .

Nu c lila b B.V .

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Neuroendocrine Perturbations

in Human Obesity

Proefschrift

ter verkrijging van de graad van Doctor

aan de U niversiteit Leiden

op gezag van de Rector Magnificus Dr. D.D. Breimer,

hoogleraar in de faculteit der W iskunde en

Natuurw etenschappen en die der G eneeskunde,

volgens het besluit van het C ollege voor Promoties

te verdedigen op maandag 3 april 2006

te klokke 14.15 uur

door

Petra K ok

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Contents

Chapter 1

General Introduction

. . . .

Page

9

Chapter 2

PRL obese vs. lean

. . . .

Page

27

Chapter 3

PRL before and after weight loss

. . . .

Page

37

Chapter 4

T SH obese vs. lean

. . . .

Page

49

Chapter 5

T SH before and after weight loss

. . . .

Page

61

Chapter 6

GH and Acipimox

. . . .

Page

69

Chapter 7

HPA ax is and Acipimox

. . . .

Page

79

Chapter 8

Bromocriptine and metabolic profiles

. . . .

Page

95

Chapter 9

Bromocriptine and leptin

. . . .

Page 107

Chapter 10

Summary and Discussion

. . . .

Page 115

S amen v attin g

. . . .

Page 129

Cu rricu lu m V itae

. . . .

Page 135

Pu b licaties

. . . .

Page 137

N aw oord

. . . .

Page 139

A ppen d ix A

Abbreviations

. . . .

Page 141

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