University of Groningen
Heart disease in women and men
van der Ende, Maaike Yldau
DOI:10.33612/diss.103508645
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Publication date: 2019
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van der Ende, M. Y. (2019). Heart disease in women and men: insights from Big Data. Rijksuniversiteit Groningen. https://doi.org/10.33612/diss.103508645
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HEART DISEASE IN WOMEN AND MEN
INSIGHTS FROM BIG DATA
COLOPHON
Cover design: Design Your Thesis | www.designyourthesis.com Layout: Design Your Thesis | www.designyourthesis.com Print: Ridderprint | www.ridderprint.nl
ISBN: 978-94-6375-609-9
Financial support by the following sponsor for the publication of this thesis is gratefully acknowledged: Rijksuniversiteit Groningen, Groningen University Institute for Drug Exploration (GUIDE).
Copyright © 2019 by Maaike Yldau van der Ende. All rights reserved. Any unauthorized reprint or use of this material is prohibited. No part of this thesis may be reproduced, stored or transmitted in any form or by any means, without written permission of the author or, when appropriate, of the publishers of the publications.
Heart Disease in Women and Men
Insights from Big Data
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. C. Wijmenga en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op woensdag 18 december 2019 om 14:30 uur
door
Maaike Yldau van der Ende
geboren op 10 maart 1993 te Noordoostpolder
Promotores
Prof. dr. P. van der Harst Prof. dr. H. Snieder Copromotor Dr. E. Lipsic Beoordelingscommissie Prof. dr. B.H.Ch. Stricker Prof. dr. J.L. Hillege Prof. dr. F.W. Asselbergs
Financial support by the Dutch Heart Foundation for the publication of this thesis is gratefully acknowledged.
Paranimfen
Drs. Rixt Marije van der Ende
Chapter 1. General introduction 9
I. PREVALENCE AND PREVENTION OF CARDIOVASCULAR DISEASE AND RISK FACTORS
Chapter 2. The Lifelines cohort study: prevalence and treatment ofcardiovascular disease and risk factors
23
Chapter 3. The effect of feedback on cardiovascular risk factors on optimization of primary prevention: a population based cohort study
43
Chapter 4. Population-based values and abnormalities of the
electrocardiogram in the general Dutch population: the Lifelines cohort study
61
Chapter 5. Resting heart rate and coronary artery disease: a genome-wide meta-analysis and Mendelian randomization analysis
85
II. UNRECOGNIZED MYOCARDIAL INFARCTION
Chapter 6. Prevalence of electrocardiographic unrecognized myocardial infarction and its association with mortality
107
Chapter 7. Sex-based differences in unrecognized myocardial infarction 125
III. LEFT VENTRICULAR HYPERTROPHY
Chapter 8. The Groningen electrocardiographic criteria for left ventricular hypertrophy: a sex-specific analysis
149
Chapter 9. Causal pathways from blood pressure to larger QRS amplitudes: a Mendelian randomization study
169
Chapter 10. Effect of systolic blood pressure on left ventricular structure and
function: a Mendelian randomization study
189
Chapter 11. General discussion and future perspectives 211
Chapter 12. Nederlandse samenvatting 225
Appendix. Dankwoord 237
Curriculum Vitae 241 List of publications 243
