University of Groningen
Congenital heart disease : the timing of brain injury
Mebius, Mirthe Johanna
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Mebius, M. J. (2018). Congenital heart disease : the timing of brain injury. [S.n.].
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Congenital heart disease:
the timing of brain injury
The printing of this thesis was financially supported by University of Groningen, University Medical Center Groningen, postgraduate school for Behavioral and Cognitive Neurosciences.
Congenital heart disease: the timing of brain injury Mirthe Mebius, The Netherlands, 2018
ISBN: 978-94-034-0355-7 ISBN (PDF): 978-94-034-0354-0 Printed by: Ridderprint BV Layout: Jos Hendrix
Coverdesign: Amanda Gautier, Gautier Scientific Illustration © 2018 M.J. Mebius, Groningen, The Netherlands
The copyright of the articles that have been published has been transferred to the respective journals. No parts of this thesis may be reproduced or transmitted in any form by any means, without prior permission of the copyright owner.
Congenital heart disease:
the timing of brain injury
Proefschrift
ter verkrijging van de graad doctor aan de
Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken
en volgens het besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op
woensdag 31 januari 2018 om 16:15 uur
door
Mirthe Johanna Mebius
geboren op 1 mei 1991
te Smallingerland
Promotores
Prof. dr. A.F. Bos
Prof. dr. C.M. Bilardo
Prof. dr. R.M.F. Berger
Copromotor
Dr. E.M.W. Kooi
Beoordelingscommissie
Prof. mr. dr. A.A.E. Verhagen
Prof. dr. J.M. Simpson
Prof. dr. M.J.N.L. Benders
Table of contents
Chapter 1 General introduction and outline of the thesis 7
Part I
Literature overview
15Chapter 2 Brain injury and neurodevelopmental outcome in congenital 17 heart disease: a systematic review
Pediatrics July 2017; pii: e20164055. doi: 10.1542/peds.2016-4055
Part II
Prenatal and postnatal cerebral findings
65 Chapter 3 Growth patterns and cerebro-placental hemodynamics in fetuses 67with congenital heart disease
Submitted
Chapter 4 Cerebral oxygen saturation during the first 72 h after birth in infants 83 diagnosed prenatally with congenital heart disease
Early Hum Dev Dec 2016; 03: 19-0
Chapter 5 Cerebral and renal oxygen saturation are not compromised in the presence 97 of retrograde blood flow in either the ascending or descending aorta in
term or near-term infants with left-sided obstructive lesions
Neonatology July 2017; 112: 217-224
Chapter 6 Association between prenatal Doppler flow patterns, head circumference 111 and postnatal cerebral oxygen saturation in term infants with congenital
heart disease
Submitted
Chapter 7 Amplitude-integrated electroencephalography during the first 72 hours 127 after birth in neonates diagnosed prenatally with congenital heart disease
Pediatric Research: in press
Chapter 8 Near-infrared spectroscopy as a predictor of clinical deterioration: a case 143 report of two infants with duct-dependent congenital heart disease
BMC Pediatr March 2017 17:79
Part III
Neurodevelopmental outcome
153Chapter 9 Onset of brain injury in infants with severe congenital heart disease: 155 a prospective longitudinal cohort study
Submitted
Chapter 10 General discussion 175
Chapter 11 Summary in English 197
Nederlandse samenvatting 201
Abbreviations 205
Dankwoord 207
