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Alcohol septal ablation

Liebregts, Max

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.

Document Version

Publisher's PDF, also known as Version of record

Publication date: 2018

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Liebregts, M. (2018). Alcohol septal ablation: Improving the treatment of obstructive hypertrophic cardiomyopathy. Rijksuniversiteit Groningen.

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Alcohol Septal Ablation

Improving the Treatment of Obstructive Hypertrophic Cardiomyopathy

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Alcohol Septal Ablation: Improving the Treatment of Obstructive Hypertrophic Cardiomyopathy

Academic thesis, University of Groningen, Groningen, the Netherlands Author Max Liebregts

Cover design Sjoerd Bongertman

Print Gildeprint Drukkerijen, Enschede, the Netherlands ISBN 978-94-034-0377-9

© M. Liebregts, Amsterdam, the Netherlands 2018

All rights reserved. No part of this publication may be reproduced, stored, or transmitted in any form or by any means, without written permission of the author.

Financial support by the Dutch Heart Foundation for the publication of this thesis is gratefully acknowledged.

Additional financial support was generously provided by Bayer B.V., Cardialysis B.V., ChipSoft B.V., de Maatschap Cardiologie en de Raad van Bestuur van het St. Antonius Ziekenhuis, Pfizer B.V., Servier Nederland Farma B.V., Stichting Wetenschap en Onderzoek Interne Geneeskunde OLVG, het UMCG.

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Alcohol Septal Ablation

Improving the Treatment of Obstructive Hypertrophic Cardiomyopathy

Proefschrift

ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen

op gezag van de

rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties.

De openbare verdediging zal plaatsvinden op

maandag 26 februari 2018 om 12.45 uur

door

Max Liebregts

geboren op 20 mei 1987 te Leiden

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Promotor

Prof. dr. Pim van der Harst

Copromotor

Dr. Jurriën M. ten Berg

Beoordelingscommissie

Prof. dr. D.E. Atsma Prof. dr. A.C. van Rossum Prof. dr. M.P. van den Berg

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Table of contents

I. INTRODUCTION

CHAPTER 1 Outline of the thesis

CHAPTER 2 Alcohol septal ablation for obstructive hypertrophic cardiomyopathy: a word of endorsement

Journal of the American College of Cardiology 2017

II. NEEDLE VS KNIFE

CHAPTER 3 Long-term outcomes after medical and invasive treatment in patients with hypertrophic cardiomyopathy

JACC Heart Failure 2014

CHAPTER 4 A systematic review and meta-analysis of long-term outcomes after septal reduction therapy in patients with hypertrophic cardiomyopathy

JACC Heart Failure 2015

III. ALCOHOL AND ITS EFFECTS

CHAPTER 5 Effect of alcohol dosage on long-term outcomes after alcohol septal ablation in patients with hypertrophic cardiomyopathy

Catheter Cardiovascular Interventions 2016

CHAPTER 6 Long-term clinical outcome after alcohol septal ablation for obstructive hypertrophic cardiomyopathy: results from the Euro-ASA registry

European Heart Journal 2016

IV. EXPANDING THE INDICATION

CHAPTER 7 Long-term outcome of alcohol septal ablation for obstructive hypertrophic cardiomyopathy in the young and the elderly

JACC Cardiovascular Interventions 2016

CHAPTER 8 Outcome of alcohol septal ablation in younger patients with obstructive hypertrophic cardiomyopathy

JACC Cardiovascular Interventions 2017

12 16 34 50 76 92 110 128

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V. ADVERSE ARRHYTHMIC EVENTS

CHAPTER 9 Validation of the HCM Risk-SCD model for patients with hypertrophic cardiomyopathy following alcohol septal ablation

Europace 2017

CHAPTER 10 Summary, discussion and future perspectives

VI. APPENDIX

Nederlandse samenvatting Contributing authors List of publications About the author Dankwoord 152 166 181 191 193 195 196

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Outline of the Thesis

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INTRODUCTION

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