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University of Groningen

Diagnosis of pemphigoid diseases

Meijer, Joost Martien

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.

Document Version

Publisher's PDF, also known as Version of record

Publication date: 2018

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Meijer, J. M. (2018). Diagnosis of pemphigoid diseases. Rijksuniversiteit Groningen.

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Diagnosis of pemphigoid diseases

J.M. Meijer 2018

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ISBN: 978-94-034-1128-6

ISBN: 978-94-034-1127-9 (e-book)

© Copyright 2018 J.M. Meijer, The Netherlands

No part of this thesis may be reproduced in any form or by any means, without prior permis-sion of the author. The copyrights of the publications remain with the publisher, unless stated otherwise.

Publication of this thesis was financially supported by Department of Dermatology, University Medical Center Groningen, University of Groningen, GUIDE.

Financial support by Junior Scientific Masterclass Groningen AGIKO program for part of the research described in this thesis is gratefully acknowledged.

Design: J.M. Meijer en A.E. Koops Lay-out: J.M. Meijer en A.E. Koops Printed by: Gildeprint

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Diagnosis of Pemphigoid Diseases

Proefschrift

ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen

op gezag van de

rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties.

De openbare verdediging zal plaatsvinden op maandag 5 november 2018 om 12.45 uur

door

Joost Martien Meijer

geboren op 13 februari 1987 te Beilen

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Promotor Prof. dr. M.F. Jonkman Copromotor Dr. H.H. Pas Beoordelingscommissie Prof. dr. P. Joly Prof. dr. M.H. Vermeer Prof. dr. P. Heeringa

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Paranimfen Dr. Jeroen Bremer Dr. Antoni Gostyński

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Table of contents

chapter

general introduction

historical perspective of pemphigoid diseases in the Netherlands: from blisterhead cow to nonbullous pemphigoid

nonbullous pemphigoid: a systematic review

prevalence of circulating bullous pemphigoid-specific igg autoantibodies in elderly patients with a nonbullous skin disorder

Optimal diagnostic strategy for bullous and nonbullous pemphigoid: a paired multivariable diagnostic

accuracy study

prevalence of pruritus and pemphigoid in nursing home residents (SSENIOR): a cross sectional study of an under-recognized disease

the n- versus u-serration is a learnable criterion to differentiate pemphigoid from epidermolysis bullosa acquisita in direct immunofluorescence serration pattern analysis

serration pattern analysis for

differentiating epidermolysis bullosa acquisita from other pemphigoid diseases

detection of u-serrated patterns in direct immunofluorescence images of autoimmune bullous diseases by

inhibition-augmented cosfire filters

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chapter

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3

chapter

47

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chapter

63

chapter 5

69

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chapter

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chapter

12

7

chapter

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laboratory diagnosis and clinical profile of anti-p200 pemphigoid

current practice in treatment approach for bullous pemphigoid: comparison between national surveys from the Netherlands and the UK

General discussion and future perspectives summary samenvatting list of publications dankwoord curriculum vitae

chapter

1

chapter

1

1

chapter

chapter

19

appendices

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13

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chapter 14

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List of Abbrevations

IgA IgG BMZ BP BP180 BP230 C3c Col7 DIF EBA EBMZ ELISA IIF IIF MO IIF SSS NaCl NC16A NRS PD VAS immunoglobulin A immunoglobulin G basement membrane zone bullous pemphigoid 180-kDa BP antigen 230-kDa BP antigen

complement 3c / complement C3 type VII collagen

direct immunofluorescence epidermolysis bullosa acquisita epidermal basement membrane zone enzyme-linked immuno sorbent assay indirect immunofluorescence

indirect immunofluorescence on monkey oesophagus substrate indirect immunofluorescence on salt-split skin substrate sodium chloride

16th non-collagenous domain BP180 / non-collagenous 16th domain A of BP180 numeric rating scale

pemphigoid diseases visual analog scale

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