University of Groningen
New insights into the pathophysiology and evaluation of fecal incontinence
van Meegdenburg, Maxime
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Publication date:
2018
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van Meegdenburg, M. (2018). New insights into the pathophysiology and evaluation of fecal incontinence.
Rijksuniversiteit Groningen.
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A
B
C
Damage of anal mucosa
Contact receptors
AESCR more
sensitive
Overreaction AESCR
EAS spasm
↑ MABP
↓ Anodermal perfusion
Local ischemia
Poor healing
CAF
IAS spasm
Pain? Current thinking New hypothesisAcute anal fissure
Regulated
by brain
Regulated by
spinal reflex
CAF
Botox injections into anal sphincter EAS relaxation ↓ MABP ↑ Anodermal perfusion Healing anal (sub)mucosa Contactreceptor AESCR less sensitive
↓ Overreaction AESCR Healing CAF Permanent normalisation MABP (also after disappearance Botox effect) Figure 3.
1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. 20. 21. 22.
23. 24. 25. 26. 27. 28. 29. 30. 31. 32. 33. 34. 35. 36. 37. 38.
