University of Groningen
Studies on the role of dopamine and serotonin in tumors and their microenvironment Peters, Marloes A.M.
DOI:
10.33612/diss.135597229
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Publication date: 2020
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Peters, M. A. M. (2020). Studies on the role of dopamine and serotonin in tumors and their microenvironment. University of Groningen. https://doi.org/10.33612/diss.135597229
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548127-L-bw-Peters 548127-L-bw-Peters 548127-L-bw-Peters 548127-L-bw-Peters Processed on: 17-9-2020 Processed on: 17-9-2020 Processed on: 17-9-2020
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Studies on the role of dopamine
and serotonin in tumors and
their microenvironment
548127-L-bw-Peters 548127-L-bw-Peters 548127-L-bw-Peters 548127-L-bw-Peters Processed on: 17-9-2020 Processed on: 17-9-2020 Processed on: 17-9-2020
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© Copyright 2020, Marloes Peters
All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means without prior permission of the author and the publisher holding copyright of the published articles.
Lay-out - Marloes Peters Printing - Ipskamp Printing
Publication of this thesis was financially supported by: Stichting Werkgroep Interne Oncologie
University of Groningen
Studies on the role of dopamine
and serotonin in tumors and their
microenvironment
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. C. Wijmenga en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op maandag 26 oktober 2020 om 9.00 uur
door
Marloes Anna Maria Peters geboren op 17 september 1989
548127-L-bw-Peters 548127-L-bw-Peters 548127-L-bw-Peters 548127-L-bw-Peters Processed on: 17-9-2020 Processed on: 17-9-2020 Processed on: 17-9-2020
Processed on: 17-9-2020 PDF page: 3PDF page: 3PDF page: 3PDF page: 3
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© Copyright 2020, Marloes Peters
All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means without prior permission of the author and the publisher holding copyright of the published articles.
Lay-out - Marloes Peters Printing - Ipskamp Printing
Publication of this thesis was financially supported by: Stichting Werkgroep Interne Oncologie
University of Groningen
Studies on the role of dopamine
and serotonin in tumors and their
microenvironment
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. C. Wijmenga en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op maandag 26 oktober 2020 om 9.00 uur
door
Marloes Anna Maria Peters geboren op 17 september 1989
548127-L-bw-Peters 548127-L-bw-Peters 548127-L-bw-Peters 548127-L-bw-Peters Processed on: 17-9-2020 Processed on: 17-9-2020 Processed on: 17-9-2020
Processed on: 17-9-2020 PDF page: 4PDF page: 4PDF page: 4PDF page: 4
Promotor
Prof. dr. I.P. Kema
Copromotores
Dr. S.F. Oosting Dr. A.M.E. Walenkamp Dr. J. Meijer
Beoordelingscommissie
Prof. dr. R.A. Wevers Prof. dr. J.A. Gietema Prof. dr. T.P. Links
548127-L-bw-Peters 548127-L-bw-Peters 548127-L-bw-Peters 548127-L-bw-Peters Processed on: 17-9-2020 Processed on: 17-9-2020 Processed on: 17-9-2020
Processed on: 17-9-2020 PDF page: 5PDF page: 5PDF page: 5PDF page: 5
Promotor
Prof. dr. I.P. Kema
Copromotores
Dr. S.F. Oosting Dr. A.M.E. Walenkamp Dr. J. Meijer
Beoordelingscommissie
Prof. dr. R.A. Wevers Prof. dr. J.A. Gietema Prof. dr. T.P. Links
548127-L-bw-Peters 548127-L-bw-Peters 548127-L-bw-Peters 548127-L-bw-Peters Processed on: 17-9-2020 Processed on: 17-9-2020 Processed on: 17-9-2020
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CONTENTS
Chapter 1 Introduction to the thesis 9
Chapter 2 Dopamine and serotonin regulate tumor behavior 19 by affecting angiogenesis.
Chapter 3 The dopamine receptor D2 agonist quinpirole inhibits 47 angiogenesis in an in ovo ovarian cancer model
Chapter 4 Serotonin and dopamine receptor expression in 61 solid tumours including rare cancers
Chapter 5 Platelet serotonin concentrations are lower in renal cell 79 carcinoma and pancreatic neuroendocrine tumor patients compared to healthy individuals: a role for indoleamine 2,3-dioxygenase?
Chapter 6 Use of selective serotonin reuptake inhibitors is associated 101 with very low plasma free serotonin concentrations in
humans
Chapter 7 Melatonin is not stored in platelets 113
Chapter 8 Discussion, conclusion and future perspectives 123
Chapter 9 Nederlandse samenvatting 135
Appendix Dankwoord 143
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CONTENTS
Chapter 1 Introduction to the thesis 9
Chapter 2 Dopamine and serotonin regulate tumor behavior 19 by affecting angiogenesis.
Chapter 3 The dopamine receptor D2 agonist quinpirole inhibits 47 angiogenesis in an in ovo ovarian cancer model
Chapter 4 Serotonin and dopamine receptor expression in 61 solid tumours including rare cancers
Chapter 5 Platelet serotonin concentrations are lower in renal cell 79 carcinoma and pancreatic neuroendocrine tumor patients compared to healthy individuals: a role for indoleamine 2,3-dioxygenase?
Chapter 6 Use of selective serotonin reuptake inhibitors is associated 101 with very low plasma free serotonin concentrations in
humans
Chapter 7 Melatonin is not stored in platelets 113
Chapter 8 Discussion, conclusion and future perspectives 123
Chapter 9 Nederlandse samenvatting 135
Appendix Dankwoord 143
548127-L-bw-Peters 548127-L-bw-Peters 548127-L-bw-Peters 548127-L-bw-Peters Processed on: 17-9-2020 Processed on: 17-9-2020 Processed on: 17-9-2020
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