University of Groningen
Chronic kidney disease
Thio, C. H. L.
DOI:
10.33612/diss.133648108
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2020
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Thio, C. H. L. (2020). Chronic kidney disease: Insights from social and genetic epidemiology. University of
Groningen. https://doi.org/10.33612/diss.133648108
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C H R O N I C K I D N E Y D I S E A S E
Insights from social and genetic epidemiology
Chris Thio
Chronic kidney disease
Insights from social and genetic epidemiology
PhD dissertation University of Groningen, the Netherlands
The publication of this thesis was financially supported by University of Groningen, University Medical Center Groningen, Science in Healthy Ageing and healthcaRE (SHARE) Research institute, and Graduate School of Medical Sciences (GSMS).
Cover design and illustrations: Senne Trip • www.sennetrip.com Layout: Igor Wever
Print: Ridderprint | www.ridderprint.nl
ISBN: 978-94-034-2609-9 (print version) ISBN: 978-94-034-2608-2 (electronic version)
© C.H.L. Thio 2020
All rights reserved. No part of this publication may be reproduced, copied, modified, stored in a retrieval system or transmitted without express written permission from the author and, when appropriate, the publisher holding the copyrights of the published articles.
Chronic kidney disease
Insights from social and genetic epidemiology
Proefschrift
ter verkrijging van de graad van doctor aan de
Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. C. Wijmenga
en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op
woensdag 7 oktober 2020 om 12.45 uur
door
Christian Han Liong Thio
geboren op 28 november 1983
te Hoogeveen
Promotores
Prof. dr. H. Snieder Prof. dr. R.T. Gansevoort Prof. dr. U. BültmannBeoordelingscommissie
Prof. dr. A. Koettgen Prof. dr. P.D. Koellinger Prof. dr. V.V.A.M. KnoersParanimfen
Peter van der Most Eliza Fraszczyk Anna Neustaeter
CONTENTS
CHAPTER 1. General introduction and thesis outline
PART I
CHAPTER 2.
Educational level and risk of chronic kidney disease: Longitudinal data from the PREVEND study
CHAPTER 3
.
Heart rate variability and its relation to chronic kidney disease: Results from the PREVEND StudyPART II
CHAPTER 4. Familial aggregation of chronic kidney disease and heritability of renal biomarkers in the general population: The Lifelines Cohort Study
CHAPTER 5
.
Evaluation of a genetic risk score based on creatinine- estimated glomerular filtration rate and its association with kidney outcomesCHAPTER 6
.
Genome-wide association scan of serum urea in European populations identifies two novel lociPART III
CHAPTER 7. The effects of genetic factors, educational attainment, and their interaction on kidney function outcomes
CHAPTER 8. Investigating causal effects of educational attainment on kidney outcomes: a Mendelian randomization study
CHAPTER 9.
General discussion
CHAPTER 10.
Nederlandse samenvatting
Acknowledgements/dankwoord About the author
List of publications
Previous SHARE dissertations
9 25 45 67 99 117 139 163 191 223 235 241 243 247
