Discovery of dormancy associated antigens of Mycobacterium tuberculosis : novel targets for the development of post-exposure or therapeutic tuberculosis vaccines

development of post-exposure or therapeutic tuberculosis vaccines

Lin, M.Y.

Citation

Lin, M. Y. (2009, December 15). Discovery of dormancy associated antigens of Mycobacterium tuberculosis : novel targets for the development of post- exposure or therapeutic tuberculosis vaccines. Retrieved from

https://hdl.handle.net/1887/14507

Version: Corrected Publisher’s Version

License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden

Downloaded from: https://hdl.handle.net/1887/14507

Note: To cite this publication please use the final published version (if applicable).







Discoveryofdormancyassociatedantigens

of Mycobacteriumtuberculosis:



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Discoveryofdormancyassociatedantigens

of Mycobacteriumtuberculosis:



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†‡‰”ƒƒ†˜ƒ‘…–‘”ƒƒ†‡‹˜‡”•‹–‡‹–‡‹†‡ǡ

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˜‘Ž‰‡•„‡•Ž—‹–˜ƒŠ‡–‘ŽŽ‡‰‡˜‘‘””‘‘–‹‡•

–‡˜‡”†‡†‹‰‡‘’†‹•†ƒ‰ͳͷ†‡…‡„‡”ʹͲͲͻ

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MinYongLin

‰‡„‘”‡–‡”‘‹‰‡‹ͳͻ͹ͺ

 

Promotor:

”‘ˆǤ”ǤǤǤǤ––‡Š‘ˆˆ



Copromotor: 

”ǤǤǤŽ‡‹(RijksinstituutvoorVolksgezondheidenMilieu,Bilthoven)



Overigeleden: 

”‘ˆǤ”ǤǤǤ‹‡•–”ƒ

™Ǥ”ǤǤ—›‰‡(WetenschappelijkInstituutVolksgezondheid,Brussel)

”‘ˆǤ”ǤǤ ǤǤ‡Ž‹‡ˆ

”‘ˆǤ”Ǥ ǤǤǤ˜ƒ—––‡(UniversiteitUtrechtȌ















̹ʹͲͲͻǡǤǤ‹ǡ‡‹†‡ǡŠ‡‡–Š‡”Žƒ†•Ǥ

ǣͻ͹ͺǦͻͲǦͻͲʹͶ͹͸͸Ǧ͵

”‹–‡†„›ǣ‹Ž†‡’”‹–”—‡”‹Œ‡Ȃ•…Š‡†‡ǡŠ‡‡–Š‡”Žƒ†•

‹‡–•—‹–†‡œ‡—‹–‰ƒ˜‡ƒ‰˜‡”˜‡‡Ž˜‘—†‹‰†‡Ȁ‘ˆ‘’‡„ƒƒ”‰‡ƒƒ–™‘”†‡œ‘†‡”

˜‘‘”ƒˆ‰ƒƒ†‡•…Š”‹ˆ–‡Ž‹Œ‡–‘‡•–‡‹‰˜ƒ†‡ƒ—–‡—”Ǥ‘’ƒ”–‘ˆ–Š‹•–Š‡•‹•ƒ›„‡

”‡’”‘†—…‡†‹ƒ›ˆ‘”™‹–Š‘—–™”‹––‡’‡”‹••‹‘ˆ”‘–Š‡ƒ—–Š‘”Ǥ

‘˜‡”ǣMycobacteriumtuberculosis

‘˜‡”‡•‹‰ǣ”ƒ†‡ ƒ‰‡”

ƒ›‘—–ǣƒ›‘—‰‹

Š‡•–—†‹‡•†‡•…”‹„‡†‹–Š‹•–Š‡•‹•™‡”‡’‡”ˆ‘”‡†ƒ––Š‡‡’ƒ”–‡–‘ˆˆ‡…–‹‘—•

‹•‡ƒ•‡• ƒ† ƒ– –Š‡ ‡’ƒ”–‡– ‘ˆ —‘Š‡ƒ–‘Ž‘‰› Ƭ Ž‘‘† ”ƒ•ˆ—•‹‘ ƒ– –Š‡

‡‹†‡ ‹˜‡”•‹–› ‡†‹…ƒŽ ‡–”‡ ƒ† ™ƒ• ˆ—†‡† „› –Š‡ ‘—†ƒ–‹‘ ‹…”‘„‹‘Ž‘‰›

‡‹†‡ ȋ–‹…Š–‹‰ ‹…”‘„‹‘Ž‘‰‹‡ ‡‹†‡Ȍǡ  Šƒ”ƒ…‡—–‹…ƒŽ• ǤǤǡ ƒ† –Š‡ Ǧ ͸

’”‘Œ‡…–ǦǤ

•‡†„›’‡”‹••‹‘ǢŠƒ’–‡”ͳƬͺǦ̹ʹͲͲͺ‡–Šƒ…‹‡…‡—„Ž‹•Š‡”•–†Ǥƒ†̹

ʹͲͲͺ„›ƒŽ–‡”†‡”—›–‡”^x‡”Ž‹^x‡™‘”

—„Ž‹…ƒ–‹‘‘ˆ–Š‹•–Š‡•‹•™ƒ•ˆ‹ƒ…‹ƒŽŽ›•—’’‘”–‡†„›—„‡”…—Ž‘•‹• ‘—†ƒ–‹‘ǡ

Ǧ›‡…Š‹‘•…‹‡…‡•ǡ‹‘•…‹‡…‡•ƒ†Ž‡ƒ‹”‡…Š‹‡ǤǤ





 

 

     

 

 

 

        

 

 

 

 

 

 





















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CONTENTS



Šƒ’–‡”ǣ

ͳ ‡‡”ƒŽ‹–”‘†—…–‹‘       ͳͳ

 ^

 EndocrMetabImmuneDisordDrugTargets.2008Mar;8(1):1529

 BiolChem.2008May;389(5):497511.

ʹ —ƒǦ…‡ŽŽ”‡•’‘•‡•–‘ʹͷ‘˜‡Žƒ–‹‰‡•‡…‘†‡†„›‰‡‡•‘ˆ–Š‡Ͷͳ

 †‘”ƒ…›”‡‰—Ž‘‘ˆMycobacteriumtuberculosis

 ^

 MicrobesInfect.2006Jul;8(8):20522060.

͵ †‡–‹ˆ‹…ƒ–‹‘‘ˆͶ^Ϊƒ†ͺ^Ϊ…‡ŽŽ”‡•’‘•‡•–‘Mycobacteriumͷ͹

 tuberculosis‘•”‡‰—Ž‘‡…‘†‡††‘”ƒ…›ƒ–‹‰‡•ƒ†ƒ’’‹‰

 ‘ˆ…Žƒ••ƒ†”‡•–”‹…–‡†’‡’–‹†‡Ǧ‡’‹–‘’‡•



 Manuscriptinpreparation



Ͷ ƒ…‘ˆ‹—‡”‡•’‘•‡•–‘Mycobacteriumtuberculosis‘•”‡‰—Ž‘ͺͷ

 ’”‘–‡‹•ˆ‘ŽŽ‘™‹‰Mycobacteriumbovis˜ƒ……‹ƒ–‹‘



 InfectImmun.2007Jul;75(7):35233530.



ͷ Ǧ…‡ŽŽ”‡…‘‰‹–‹‘‘ˆ–Š‡•’’”‘–‡‹‘ˆMycobacteriumtuberculosisͳͲ͵

 …‘””‡Žƒ–‡•™‹–ŠŽƒ–‡–M.tuberculosis‹ˆ‡…–‹‘„—–‘–™‹–Š

 M.bovis˜ƒ……‹ƒ–‹‘

 InfectImmun.2007Jun;75(6):29142921



͸ ”‘••Ǧ”‡ƒ…–‹˜‡‹—‹–›–‘Mycobacteriumtuberculosis‘•ͳͳͻ

 ”‡‰—Ž‘Ǧ‡…‘†‡†ƒ–‹‰‡•‹‹†‹˜‹†—ƒŽ•‹ˆ‡…–‡†™‹–Š‡˜‹”‘‡–ƒŽǡ

 ‘Ǧ–—„‡”…—Ž‘—•›…‘„ƒ…–‡”‹ƒ

 ^

 InfectImmun.2009Nov:77(11):50715079



͹ —Ž‘ƒ”›†‡Ž‹˜‡”›‘ˆ‡…‘†‹‰MycobacteriumtuberculosisͳͶ͵

 Žƒ–‡…›ƒ–‹‰‡˜ͳ͹͵͵…ƒ••‘…‹ƒ–‡†–‘Ǧƒ‘’ƒ”–‹…Ž‡•^

 ‡Šƒ…‡•…‡ŽŽ”‡•’‘•‡•‹ƒ’”‹‡Ȁ’”‘–‡‹„‘‘•–˜ƒ……‹ƒ–‹‘^

 ”‡‰‹‡‹‹…‡^



 Vaccine.2009Jun19;27(30):40104017^

ͺ —ƒ”›ƒ†‡‡”ƒŽ‹•…—••‹‘    ͳ͸ͳ

 ‡†‡”Žƒ†•‡ƒ‡˜ƒ––‹‰     ͳ͹ͷ

 …‘™Ž‡†‰‡‡–•      ͳ͹ͻ

 —””‹…—Ž—‹–ƒ‡      ͳͺͳ

 ‹•–‘ˆ—„Ž‹…ƒ–‹‘•      ͳͺ͵

 ‹•–‘ˆ„„”‡˜‹ƒ–‹‘•      ͳͺͷ