Dinuclear Platinum Complexes as potential anticancer drugs : insights
in the intracellular distribution
Kalayda, G.V.
Citation
Kalayda, G. V. (2006, February 1). Dinuclear Platinum Complexes as potential anticancer drugs : insights in the intracellular distribution. Retrieved from
https://hdl.handle.net/1887/4283
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in theInstitutional Repository of the University of Leiden Downloaded from: https://hdl.handle.net/1887/4283
Propositions belonging to the thesis
Dinuclear platinum complexes as potential anticancer drugs: insights in the intracellular distribution
1. A number of cancer types exist, each having its own specific features. Drug behavior varies significantly between different cancers. This is the biggest challenge for cancer chemotherapy.
This thesis
2. Drug sequestration in lysosomes partly accounts for cisplatin resistance and cross-resistance in some tumors.
This thesis
3. Design of drug delivery systems based on platinum coordination compounds presents an alternative to the widely used covalent coupling of drugs to targeting proteins.
This thesis
4. Toxicity studies are as important as cytotoxicity tests in the evaluation of clinical usefulness of new potential drug candidates.
This thesis
5. In general, resistance is multifactorial, in that several mechanisms are encountered simultaneously within the same tumor cell. Thus, versatility of cisplatin resistance makes it so difficult to overcome.
Z. H. Siddik Oncogene 2003, 22, 7265. This thesis
6. Understanding the molecular profile of human tumors is essential to the effective use of cancer drugs.
B. A. Chabner, T. G. Roberts Jr Nature Rev. Cancer 2005, 5, 65
7. Further research should concentrate on various methods of platinum visualization in clinically obtained specimens as a predictive tool in cisplatin chemotherapy.
8. The accidental discovery of anti-proliferative properties of cisplatin by Rosenberg and co-workers shows that serendipity can save people’s lives. B. Rosenberg et al. Nature 1965, 205, 698
B. Rosenberg et al. Nature 1969, 222, 385
9. To beat cancer, science must develop faster than cancer does.
10. Choosing for fat-free products people often think they eat healthy and forget that fat is essential for normal growth and development of an organism.
11. Introducing a fast train service between Leiden and Utrecht would mean significant progress of the railway system in the Netherlands.
