The ubiquitin proteasome system in Huntington disease : impairment of the proteolytic machinery aggravates huntingtin aggregation and toxicity

(2002) Increased huntingtin protein length reduces the number of polyglutamine-induced gene expression changes in mouse models of Huntington’s disease.. and

The mutant ubiquitin protein that is formed can no longer ubiquitinate substrate proteins but is a target for ubiquitination and subsequent proteasomal degradation.. UBB +1

Deze bevindingen impliceren dat UBB +1 de polyglutamine geïnduceerde neurodegeneratie versterkt en onderstreept het belang van het UPS voor de afbraak van misgevouwen

(2004) Accumulation of aberrant ubiquitin induces aggregate formation and cell death in polyglutamine diseases.. Repair of UV lesions in silenced chromatin provides in vivo

The Ubiquitin Proteasome System in Huntington Disease: Impairment of the proteolytic machinery aggravates huntingtin aggregation and toxicity Een efficient proteasoom is

Peripheral blood cells were stained with HLA-A2.1 tetramers containing the tyrosinase368–376 peptide followed by staining with a panel of lineage antibodies, as described in

Blades and blade fragments seem to have been especially used for longitudinal motions, mainly on plant material (7/12). Flake and flake fragments are used in different motions on

This shape also occurs in the combination artefacts (see below). The shape is the result of intensive use in a repetitive abrasive motion, carried out from different angles. In