• No results found

Cover Page The handle

N/A
N/A
Protected

Academic year: 2021

Share "Cover Page The handle"

Copied!
4
0
0

Bezig met laden.... (Bekijk nu de volledige tekst)

Hele tekst

(1)

Cover Page

The handle http://hdl.handle.net/1887/41190 holds various files of this Leiden University dissertation

Author: Voskamp, Astrid L.

Title: Clinical allergy : basophils, T cells, and therapeutic design

Issue Date: 2016-06-16

(2)

CliniCal allergy: Basophils, T Cells, and

TherapeuTiC design

(3)

CliniCal allergy: Basophils, T Cells, and TherapeuTiC design

Proefschrift

ter verkrijging van

de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof. mr. C.J.J.M Stolker,

volgens besluit van het College voor Promoties ter verdediging op donderdag 16 juni 2016

klokke uur 15.00 uur

door

Astrid Lida Voskamp geboren te Thurso (Schotland) in 1981 ISBN: 978-94-91602-63-4

© 2016 Astrid Voskamp

All rights reserved. No part of this thesis may be reproduced in any form without permission of the author.

The work presented in this thesis was performed at the Department of Immunology, Monash University, and the Department of Allergy, Immunology and Respiratory Medicine, The Alfred Hospital, Australia.

The studies described in this thesis were financially supported by the Ilhan Food Allergy Foun- dation, the National Health and Medical Research Council of Australia, The Alfred Trusts and Novartis.

Printing: Printservice Ede

(4)

CoNTENTS

Chapter 1 General Introduction

Chapter 2 Clinically relevant IgE reactivity and basophil activation to goat’s milk after cutaneous sensitization

Chapter 3 MHC Class II expression in human basophils: induction and lack of functional significance

Chapter 4 Ara h 2 peptides comprising dominant CD4

+

T-cell epitopes:

candidates for a peanut allergy therapeutic

Chapter 5 Ara h 1 CD4

+

T-cell epitope-based peptides: candidates for a peanut allergy therapeutic

Chapter 6 Cysteine-to-serine substitution can alter susceptibility of therapeutic peptides to gastrointestinal enzyme digestion, affecting potential for oral delivery

Chapter 7 Clinical efficacy and immunological effects of omalizumab in allergic bronchopulmonary aspergillosis

Chapter 8 Summarizing Discussion

Appendix Nederlandse samenvatting

Acknowledgements Curriculum Vitae

List of publications Promotors

Prof. Dr. M. Yazdanbakhsh

Prof. Dr. R.E. o’Hehir (Monash University, Australia)

Co-promotor

Dr. S.R. Prickett (Monash University, Australia)

Leden Promotiecommissie Prof. Dr. R.E.M. Toes

Prof. Dr. R. Gerth van Wijk (Erasmus Medisch Centrum, Rotterdam) Prof Dr. R. van Ree (Academic Medical Center, Amsterdam) Prof. Dr. C. Taube

Dr. H.H. Smits

9 43

49

67

95

125

139

157

171

176

178

180

Referenties

GERELATEERDE DOCUMENTEN

Voorts werd behandeld hoe op basis van deze fysiologische grond- slagen in beginsel kan worden bepaald wat gezien kan worden; het systeem voor het bepalen van

2) Multiple requests simultaneously. Also during the intervention multiple requests to pick up patients arrived simultaneously. The intervention mainly focused on

The research described in this thesis was performed at the Amsterdam Rheumatology and immunology Center, the Department of Radiology & Nuclear Medicine and VUmc Cancer Center,

The research presented in this thesis was performed at the Department of Microbiology, Immunology and Cancer Biology and the Department of Surgery at the University

The primary goal was to find as much relevant information on the topic as possible and to ultimately compile it in a coherent way, in order to facilitate the research process of

In de tweede plaats werd ingegaan op ‘experimenteren tussen wetgeving’, door het scheppen van leerzame lokale variatie tussen wet- en regelgeving op basis van decentrale

Structuur 2 (S4010, S4011, S4040, Figuur 19) is eveneens in werkput 4 aangetroffen. Deze structuur is 

This chapter provides the introduction to the study of perceived women discrimination in the South African mining industry and provided the background, the problem