University of Groningen Nanobiomaterials for biological barrier crossing and controlled drug delivery Ribovski, Lais

University of Groningen

Nanobiomaterials for biological barrier crossing and controlled drug delivery

Ribovski, Lais

DOI:

10.33612/diss.124917990

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Publication date:

2020

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Ribovski, L. (2020). Nanobiomaterials for biological barrier crossing and controlled drug delivery. University

of Groningen. https://doi.org/10.33612/diss.124917990

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Nanobiomaterials for biological

barrier crossing and controlled

drug delivery

Copyright © 2020 by Laís Ribovski

Cover: Laís Ribovski and Daniel Polistchuck

Printed by Gilderprint

ISBN (printed version): 978-94-034-2617-4

ISBN (electronic version): 978-94-034-2616-7

Nanobiomaterials for biological barrier

crossing and controlled drug delivery

PhD thesis

to obtain the degree of PhD at the

University of Groningen

on the authority of the

Rector Magnificus Prof. C. Wijmenga

and in accordance with

the decision by the College of Deans

and

to obtain the degree of PhD at the

University of São Paulo

on the authority of the

Rector Prof. V. Agopyan

and in accordance with

the decision by the Pro-Rectory of Post-Graduation

Double PhD degree

This thesis will be defended in public on

Monday 18 May 2020 at 9:00 hours

by

Laís Ribovski

born on 6 July 1989,

in Rio Negro, Paraná, Brazil

Supervisors

Dr. I. S. Zuhorn

Dr. P. van Rijn

Dr. V. Zucolotto

Dr. J. Cancino-Bernardi

Assessment Committee

Prof. dr. M.M.G. Kamperman

Prof. dr. L. De Laporte

Prof. dr. S. C.D. van IJzendoorn

Prof. dr. O. N. de Oliveira Jr.

Paranymphs

Cecilia Kollross

Gwenda Vasse

TABLE OF CONTENTS

CHAPTER 1:

INTRODUCTION AND AIM OF THIS THESIS

1

CHAPTER 2:

LOW NANOGEL STIFFNESS FAVORS NANOGEL

TRANSCYTOSIS

ACROSS

THE

BLOOD-BRAIN

BARRIER

31

CHAPTER 3:

EFFECT OF CO-CULTURE OF GLIOMA CELLS AND

MACROPHAGES ON THE INTERACTION WITH

NANOGELS OF DIFFERENT STIFFNESS

61

CHAPTER 4:

EPITHELIAL CANCER-CELL MEMBRANE COATED

PLGA NANOCARRIERS ENHANCED UPTAKE LEADS

TO MORE EFFECTIVE CANCER TREATMENT

93

CHAPTER 5:

LIGHT-INDUCED MOLECULAR ROTATION TRIGGERS

ON DEMAND DRUG RELEASE FROM LIPOSOMES

123

CHAPTER 6:

GENERAL

DISCUSSION

AND

FUTURE

PERSPECTIVES