University of Groningen
Novel strategies targeting hepatic stellate cells to reverse liver fibrosis
Shajari, Shiva
DOI:
10.33612/diss.144700577
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Publication date: 2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Shajari, S. (2020). Novel strategies targeting hepatic stellate cells to reverse liver fibrosis. University of Groningen. https://doi.org/10.33612/diss.144700577
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Stellingen
Behorende bij het proefschrift
Novel strategies targeting hepatic stellate cells
to reverse liver fibrosis
1. The name “hormone-sensitive lipase (HSL)” does not properly cover the highly variable and cell type-specific activities of this enzyme in the liver. “This thesis”
2. The activation process of hepatic stellate cells (HSC) is associated with a rapid loss of the retinyl ester hydrolyzers patatin-like phospholipase domain-containing protein 3 (PNPLA3) and HSL, but patatin-like phospholipase domain-containing protein 2 (ATGL) level remains high in activated HSC. Thus, activated HSC are still capable of hydrolyzing retinyl esters. “This thesis”
3. 5-lipoxygenase antagonists are suitable to treat liver fibrosis. “This thesis”
4. Hydroxyurea has a greater antifibrotic impact on transdifferentiating HSCs than on fully-activated ones. Thus, it is especially useful to treat liver fibrosis in early stages of liver disease. “This thesis”
5. Esculetin reverses fibrosis by stimulating degradation of extracellular matrix proteins through suppressing TIMP metallopeptidase inhibitor 1 (TIMP-1). “This thesis”
6. The president of United States received melatonin for treating the viral infection by Covid-19, which may also have helped to prevent early deterioration of lung functions by inhibiting fibrogenesis.” BBC NEWS” 7. Unlimited access to the lab, equipment and supplies is sometimes needed to go against the stream, as it led to the discovery of HSL in quiescent HSC while the general believe was that it should not be present there.
Shiva Koets-Shajari 25 November 2020
