University of Groningen
An inflamed mood
Yang, Chenghao
DOI:
10.33612/diss.98153713
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Publication date: 2019
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Yang, C. (2019). An inflamed mood: studies on the role of inflammation in the pathophysiology and treatment outcome of major depressive disorder. University of Groningen.
https://doi.org/10.33612/diss.98153713
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propositions associated with the dissertation
An inflamed mood
Studies on the role of inflammation in the pathophysiology and treatment outcome of major depressive disorder
Chenghao Yang
1. Depression and inflammation are intertwined, fueling and feeding off each other (Kiecolt-Glaser JK, 2015).
2. Increased values of serum interleukin-6 and 1β are more common in the melancholic subtype of
depression, compared to the non-melancholic subtype or healthy controls, while C-reactive protein may be a pointer for the non-melancholic subtype (Chapter 2).
3. Interleukin-6 and C-reactive protein/high-sensitivity C-reactive protein are promising markers for
predicting treatment response in treatment resistant depression, while other markers such as interleukin-2/10 and tumor necrosis factor-α were far less promising in this respect (Chapter 3).
4. N-acetylcysteine is a promising additional treatment for depression in patients with treatment resistant
depression and increased inflammatory activity (Chapter 4).
5. No significant differences are found in the distributions of FKBP5 alleles, genotypes, and haplotypes
between Han Chinese depressive cases and healthy controls or between depressed patients with and without treatment resistant depression, in terms of major depressive disorder susceptibility and antidepressant treatment response (Chapter 5).
6. CNR1 SNPs rs806367 and rs6454674 and haplotype C-T-T-C of rs806366, rs806367, rs806368, and
rs806370 are associated with increased susceptibility for major depressive disorder and antidepressant treatment resistance in Han Chinese (Chapter 6).
7. Two heads are always better than one (Confucius, the Analects of Confucius). 8. If you cannot do great things, then do small things in a great way (Napoleon Hill).
