University of Groningen
Neuroendocrine tumors; measures to improve treatment and supportive care
de Hosson, Lotte Doortje
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de Hosson, L. D. (2019). Neuroendocrine tumors; measures to improve treatment and supportive care.
Rijksuniversiteit Groningen.
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Neuroendocrine tumors;
Measures to improve treatment and supportive care.
Neuroendocrine tumors; Measures to improve treatment and supportive care Lotte D. de Hosson
PhD dissertation, University of Groningen, the Netherlands
Layout by: XML 2 Publish Printing by: Gildeprint, Enschede
ISBN: 978-94-034-1443-0
ISBN (electronic version): 978-94-034-1442-3
© Copyright 2019 – Lotte D. de Hosson, Groningen, the Netherlands
All right reserved. No part of this thesis may be reproduced, stored in a retrieval or transmitted in any form or by any means, without prior permission of the author or, when appropriate of the publisher of the published articles.
Printing of this thesis was financially supported by the Stichting Werkgroep Interne Oncologie, Rijksuniversiteit Groningen, Universitair Medisch Centrum Groningen.
Neuroendocrine tumors; Measures
to improve treatment and
supportive care
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op woensdag 20 februari 2019 om 16.15 uur
door
Lotte Doortje de Hosson
geboren op 15 januari 1985 te Maurik
Promotor
Prof. dr. E.G.E. de Vries
Copromotor
Dr. A.M.E. WalenkampBeoordelingscommissie
Prof. dr. W.W. Herder Prof. dr. H. Hollema Prof. dr. G.A.P. HospersParanimfen
Kim J.H.A. de Hosson Iris I.C. KokContents
Chapter 1 General introduction and outline of the thesis 6
Chapter 2 Clinical benefit of systemic treatment in patients with advanced
pancreatic and gastro-intestinal neuroendocrine tumors according to ESMO-MCBS and the Net Health Benefit of ASCO revised framework.
16
L.D. de Hosson, L.M. van Veenendaal, Y. Schuller, W.T. Zandee, W.W. de Herder, M.E.T. Tesselaar, H.J. Klümpen, A.M.E. Walenkamp.
Chapter 3 a) Web-based tailored information and support for patients with a
Neuroendocrine tumor; WIN-pilot. 40
G. Bouma, L.D. de Hosson, C. E. van Woerkom, H. van Essen, G.H. de Bock, J.M. Admiraal, A.K. L. Reyners, A. M. E. Walenkamp.
b) Web-based tailored nformation and support for patients with a
Neuroendocrine tumor; WIN-study 58
L.D. de Hosson*, G. Bouma*, J. Stelwagen, H. van Essen, G.H. de Bock, D.J.A. de Groot, E.G.E. de Vries, A.M.E. Walenkamp.
Chapter 4 Towards optimal personalized diet and vitamin supplementation
in NET patients; DIVIT-pilot. 78
L.D. de Hosson, J. Stelwagen, G. Bouma, B. Sijtema, S, Huitema, H.J.R. van Faassen, G.H. de Bock, D.J.A. de Groot, M.J.E. Campmans-Kuijpers, I.P. Kema, E.G.E. de Vries, A.M.E. Walenkamp.
Chapter 5 Heterogeneity in neuroendocrine tumor lesions visible with
[18F]FDOPA PET/CT 88
L.D. de Hosson, A.M. van der Loo- van der Schaaf, R. Boellaard, J. H. van Snick, E.G.E. de Vries, A. H. Brouwers, A.M.E. Walenkamp.
Chapter 6 Reasons for the cold immune microenvironment of
neuroendocrine tumours. 108
L.D. de Hosson*, G. Bouma*, G. Kats-Ugurlu, M. Bulthuis, E.G.E. de Vries, M. van Faassen, I.P. Kema, A.M.E. Walenkamp.
Chapter 7 Summary and future perspectives 126
Appendix Dutch summary, Nederlandse samenvatting 143
