University of Groningen
A lifetime with Phenylketonuria
Jahja, Rianne
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Publication date: 2017
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Jahja, R. (2017). A lifetime with Phenylketonuria: Towards a better understanding of therapeutic targets. Rijksuniversiteit Groningen.
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Stellingen
behorend bij het proefschrift
A lifetime with Phenylketonuria
Towards a better understanding of therapeutic targets
1. Childhood is a very sensitive and critical period for cognitive development. 2. High phenylalanine levels affect the brain and therefore its cognitive
development.
3. COgnition, BEhaviour and SOcial functioning are intertwined.
4. Data of this thesis suggest that an upper target Phe limit of 240 µmol/L in childhood results in even better executive functioning than the now recommended treatment target of 360 µmol/L (this thesis).
5. Childhood phenylalanine levels have the strongest effect on COBESO outcomes in adult life (this thesis).
6. In older patients with Phenylketonuria, the BESO part of the profile should be more emphasized as it is more affected and becomes more important than the CO part (this thesis).
7. Relaxing treatment/diet from adolescence onwards is not (always) favourable (this thesis).
8. Tetrahydrobiopterin (BH4) may have a positive effect on the cognitive
outcome of patients with PKU (this thesis).
9. The more I learn, the more I realize how much I don’t know (Albert Einstein). 10. Challenges are what makes life interesting and overcoming them is what
makes life meaningful (Joshua J. Marine). 11. Strive for progress, not perfection (Anonymous).
12. Life is not about waiting for the storm to pass. It’s about learning to dance in the rain (Vivian Greene).
Rianne Jahja 27 juni 2017
