University of Groningen
Towards improved and broadly protective influenza vaccines
Bhide, Yoshita
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Publication date:
2018
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Bhide, Y. (2018). Towards improved and broadly protective influenza vaccines: Focus on delivery systems,
routes of administration and animal models. Rijksuniversiteit Groningen.
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Propositions Yoshita Chandravadan Bhide
“Towards improved and broadly protective
influenza vaccines”
1. Vaccination is the foundation for the control of influenza, therefore it is very important to educate people to get vaccinated.
2. Influenza pandemics can be devastating as testified by the Spanish Flu (1918) which kil-led 50-100 million people corresponding to 3-5% of the world’s population at that time. An influenza vaccine which can provide protection against a broad range of influenza viruses and can thereby mitigate future influenza pandemics is therefore urgently nee-ded.
3. Vaccination with whole inactivated virus influenza vaccines combined with mucosal adjuvants is a promising approach for achieving protection (This thesis).
4. Pre-existing immunity could be harnessed for making an influenza vaccine broadly pro-tective, as most of the population has been exposed to influenza at least once (This thesis).
5. Studies pinpointing immune mechanisms of protection are necessary. They can guide the future development of influenza vaccine (This thesis).
6. Protection against influenza is a complex process which involves more than one immune parameter to be optimally effective (This thesis).
7. Cotton rats could be used as an animal model for influenza vaccine evaluation; however several parameters like age of the animals, virus strain used, and infection dose need to be chosen carefully (This thesis).
8. I have not failed. I’ve just found 10,000 ways that won’t work (Thomas A. Edison). 9. The highest education is that which does not merely give us information but makes our
