T cell immunity to islets of Langerhans : relevance for immunotherapy and transplantation to cure type 1 diabetes

GRAFT-SPECIFIC CYTOKINE PRODUCTION BEFORE AND AFTER TRANSPLANTATION Because cytokine production in MLC is a reflection of allograft-specific T-cell responses, quantitative differences

FIGURE 1 Overview of clinical and cellular immune parameters of five islet cell transplant recipients during tapering of immunosuppression. Shown are A) immunosuppression

In this study, it is shown that CMV viremia not only occurred earlier but was also more severe in SPK transplant recipients receiving single-shot ATG F induction therapy compared

In a cohort of standardized islet graft recipients that we analyzed with regard to immune- related factors, both pre-existent and post-transplantation T cell autoimmunity

Further- more, our studies identified, developed and validated robust and reliable tools to assess immunological efficacy in relation with clinical efficacy of immune intervention

Diabetes mellitus kan worden ingedeeld in meerdere vormen, waarvan de belangrijkste type 1 en type 2 zijn. Type 2, vroeger bekend als ‘ouderdoms-diabetes’, kenmerkt zich door

In December 2004 he started his research on the relevance of T cell immunity in type 1 diabetes, islet and pancreas transplantation, again in Leiden at the department of Surgery

Pancreas transplantation has been widely regarded as the most effective way to achieve euglycemia in patients with type 1 diabetes and end-stage renal disease.. Transplantation