Cover Page
The handle http://hdl.handle.net/1887/49072 holds various files of this Leiden University dissertation.
Author: Doorenweerd, N.
Title: The Duchenne Brain
Issue Date: 2017-06-28
Cover designed by Agnes E. Boomsma and Nathalie Doorenweerd Print & layout by proefschrift-aio.nl
ISBN: 978-90-826784-1-3
Part of the research in this thesis was funded by the Duchenne Parent Project NL and the Gratama Foundation.
Financial support for the publication of this thesis was kindly provided by Philips Healthcare, Best, The Netherlands.
© 2017 N. Doorenweerd, Leiden, The Netherlands
Copyright of the published chapters is held by the publisher of the journal in which the work appeared. All rights reserved. No part of this book may be reproduced or transmitted in any form or by any means without permission of the copyright owner.
The Duchenne Brain
Proefschrift
Ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties te verdedigen op woensdag 28 juni
klokke 13:45 uur door
Nathalie Doorenweerd Geboren te Vlissingen
in 1986
Promotor: prof.dr. J.J.G.M. Verschuuren Co-promotores: dr. H.E. Kan
dr. J.G.M. Hendriksen1
Promotiecommissie: prof.dr.Ir. S.M. van der Maarel prof.dr. B. van Engelen2
dr. P.J.W. Pouwels3
1 Kempenhaeghe Epilepsy Center, Heeze, The Netherlands and Maastricht University Medical Center, Maastricht, The Netherlands
2 Department of Neurology, Radboud University Medical Center, Nijmegen, The Netherlands
3 MS Research Center, Department of Physics and Medical Technology, VU University Medical Center, Amsterdam, The Netherlands
Contents
Chapter 1
General introduction Chapter 2
Reduced Cerebral Gray Matter and Altered White Matter in Boys with Duchenne Muscular Dystrophy
Ann. Neurol. 2014 Sep;76(3):403-11 Chapter 3
Decreased cerebral perfusion in Duchenne muscular dystrophy patients Neuromuscul. Disord. 2017 Jan;27(1):29-37
Chapter 4
Proton magnetic resonance spectroscopy indicates preserved cerebral biochemical composition in Duchenne muscular dystrophy males J. Neuromuscul. Dis. 2017;4(1):53-58
Chapter 5
Timing and localization of human dystrophin expression provide insights into the cognitive phenotype of Duchenne muscular dystrophy Under Review
Chapter 6
Summary and general discussion Nederlandse samenvatting References
Acknowledgements Curriculum Vitae List of publications