Cover Page The handle

Title: Mechanistic modelling of drug target binding kinetics as determinant of the time course of drug action in vivo.. Issue

The cellular response to NK1 receptor activation was monitored using two real-time assays, namely a cAMP assay (GloSensor) and a morphology-based assay (xCELLigence).. A

The rate-limiting step approximation for drug distribution and drug- target binding that we propose here on basis of our previous publication differs significantly from the

An integrated analysis of the influence of drug-target binding kinetics, plasma pharmacokinetics and local drug concentrations has recently revealed the role of binding kinetics

The important role of drug-target binding kinetics as a determinant of target occupancy profiles has been known for long, and both in vitro and in vivo measurements of associa- tion

In mammals, synchronization of these cell- autonomous rhythms is coordinated by neuronal and humoral signals from the suprachiasmatic nuclei (SCN) in the hypothalamus. The

This section will give an overview of the rhythms in physiological processes and provide some examples of how the exposure (pharmacokinetics) and effect (pharmacodynamics) of a

Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of