Roles of neuro-exocytotic proteins at the neuromuscular junction
Sons-Michel, M.S.
Citation
Sons-Michel, M. S. (2011, November 1). Roles of neuro-exocytotic proteins at the neuromuscular junction. Uitgeverij BOXPress, Oisterwijk. Retrieved from https://hdl.handle.net/1887/18010
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
Downloaded from: https://hdl.handle.net/1887/18010
Note: To cite this publication please use the final published version (if applicable).
Michèle S. Sons
Roles of neuro-exocytotic proteins at
the neuromuscular junction
ISBN: 978-90-8891-339-6 Cover design: Evangelia Tantalaki Printed by: Proefschriftmaken.nl
Published by: Uitgeverij BOXPress, Oisterwijk
Proefschrift
Roles of neuro-exocytotic proteins at the neuromuscular junction
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van de Rector Magnificus Prof. mr. P.F. van der Heijden, volgens besluit van het College voor Promoties
te verdedigen op dinsdag 1 november 2011 klokke 13:45 uur
door
Michèle S. Sons-Michel geboren te Amsterdam
in 1976
Promotiecommissie Promotor
Prof. Dr. J.J.G.M. Verschuuren Co-promotor
Dr. J.J. Plomp Overige leden
Prof. Dr. R.A.C. Roos Prof. Dr. J.N. Noordermeer Prof. Dr. M. Missler
Most experiments described in this thesis were performed at the:
Leiden University Medical Centre Department of Molecular Cell Biology Neurophysiology Laboratory Dr. J.J. Plomp Einthovenweg 20
P.O. box 9600 NL 2300RC Leiden The Netherlands
The studies described in this thesis were supported by grants from the
Netherlands Organisation for Scientific Research, NWO, (903-42-073), and
the Deutsche Forschungsgemeinschaft, DFG (SFB 406-C9).
Voor mijn ouders
6
Roles of neuro-exocytotic proteins in the neuromuscular junction
7 Contents
Chapter Pg.
1 General Introduction 9
2 Aberrant morphology and residual transmitter release at the
Munc13-deficient mouse neuromuscular synapse 43 3 α-Neurexins are required for efficient transmitter release and
synaptic homeostasis at the mouse neuromuscular junction 69 4 Rab3A deletion selectively reduces spontaneous neurotransmitter
release at the mouse neuromuscular synapse 99 5 Munc18-1 expression levels control synapse recovery by regulating
readily releasable pool size 117
6 Munc18-1 is involved in homeostatic upregulation of transmitter release at the myasthenic mouse neuromuscular synapse 145 7 Redundancy of RIM1α in neuromuscular synapse function 165
8 Summary and General Discussion 179
Samenvatting 191
List of publications 199
Acknowledgments 201
Curriculum Vitae 203
Contents
8
