The zebrafish as a model for tissue regeneration and bone remodelling
Sharif, F.
Citation
Sharif, F. (2011, October 12). The zebrafish as a model for tissue regeneration and bone remodelling. Retrieved from https://hdl.handle.net/1887/17923
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
Downloaded from: https://hdl.handle.net/1887/17923
Note: To cite this publication please use the final published version (if applicable).
The Zebrafish as a Model for Tissue Regeneration and Bone Remodelling
Faiza Sharif
ii
To my family, Ammi, Abbu, Khansa and Abdullah
Faiza Sharif
The Zebrafish as a Model for Tissue Regeneration and Bone Remodelling
Dissertation Leiden University
Cover Figure by Faiza Sharif and Gerda Lamers: A multinucleated osteoclast on Zebrafish scale
Cover design Faiza Sharif and Michael Richardson Copyright © 2011 by F. Sharif
iii
The Zebrafish as a Model for Tissue Regeneration and Bone Remodelling
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van de Rector Magnificus Prof. Mr. P.F. van der Heijden, volgens besluit van het College voor Promoties
te verdedigen op Woensdag 12 Oktober 2011 klokke 11:15 uur
door Faiza Sharif
geboren te Lahore, Pakistan in 1972
iv
Promotiecommissie
Promotor. Prof. Dr. Michael K. Richardson
Overig leden. Prof. Dr. Carel J. ten Cate (Leiden University) Prof. Dr. Gert Flik (Radboud University, Nijmegen) Prof. Dr. Vincent Everts (University of Amsterdam) Prof. Dr. Stefan Schulte-Merker (Hubrecht Institute, Utrecht University and Wageningen University)
Dr. Annemarie H. Meijer (Leiden University) Dr. Danielle L. Champagne (Radboud University, Nijmegen)
This work was supported by the Higher Education Commission of Pakistan and the Smart Mix Programme of the Netherlands Ministry of Economic Affairs and The Netherlands Ministry of Education, Culture and Science.
v
Contents
Chapter 1 Introduction
Chapter 2 Expression Patterns of Genes Associated with Bone and Tissue Remodelling in Early Zebrafish Embryos
Chapter 3 Mesoporous Silica Nanoparticles as a Compound Delivery System in Zebrafish Embryos
Chapter 4 Matrix Metalloproteinases in Osteoclasts of Ontogenetic and Regenerating Zebrafish Scales
Chapter 5 Acute Exposure to Dexamethasone in Early-Life is Associated with Enduring Effects on Wound Healing in Zebrafish Larvae
Chapter 6 Summary and Discussion
References
Nederlandse Sammenvatting
Acknowledgments Curriculum vitae
Conference contributions Publication
