Advanced Computed Tomography for Cardiac Applications:
From Cardiovascular Diagnosis to Clinical Management
Fleur R. de Graaf
The research described in this dissertation was conducted at the departments of Cardi- ology and Radiology of Leiden University Medical Center, Leiden, the Netherlands Design: DerijckeFormaties
Lay-out and printing: Optima Grafische Communicatie, Rotterdam, the Netherlands ISBN: 978-94-6169-172-9
Copyright © 2012 F.R. de Graaf, Leiden, the Netherlands. All rights reserved. No parts of this book may be reproduced or transmitted, in any form or by any means, without prior permission of the author.
Financial support for the costs associated with the publication of this dissertation was
gratefully received from Actelion Pharmaceuticals Nederland BV, Astellas pharma BV,
Bayer HealthCare, Boehringer Ingelheim BV, Boston Scientific Nederland BV, Bracco Im-
aging Europe BV, Foundation Imago, JE Jurriaanse Stichting, Johnson & Johnson Medical
BV, Medis Medical Imaging Systems BV, MSD Nederland BV, Nederlandse Hartstichting,
Roche Nederland BV, Servier, Toshiba Medical Systems BV, Vital Images Europe BV, Vol-
cano Europe BV.
Advanced Computed Tomography for Cardiac Applications:
From Cardiovascular Diagnosis to Clinical Management
Proefschrift
Ter verkrijging van
De graad van Doctor aan de Universiteit Leiden, Op gezag van Rector Magnificus Prof. Mr. P.F. van der Heijden,
Volgens besluit van het College voor Promoties Te verdedigen op donderdag 2 februari 2012
Klokke 16:15 uur
door
Fleur R. de Graaf
Geboren te Hilversum in 1980
PRomotiecommissie
Promotores: Prof. dr. J.J. Bax
Prof. dr. E.E. van der Wall Co-promotor Dr. L.J. Kroft
Overige leden: Prof. dr. M.J. Schalij Prof. dr. J.W. Jukema Prof. dr. J.C. Reiber
Prof. dr. G. Croiset (VUmc, Amsterdam) Dr. G. de Grooth
This research is supported by the Dutch Technology Foundation STW, which is part of
the Netherlands Organization for Scientific Research (NWO) and partly funded by the
Ministry of Economic Affairs, Agriculture and Innovation (project number 10084)
To Easwaran and Christine
Table of contents
introduction and outline
Chapter 1 Clinical application of CT coronary angiography: state of the art Based on:
Heart Lung Circ 2010
9
Part i cardiovascular Diagnosis
Chapter 2 Diagnostic accuracy of 320-row multidetector computed
tomography coronary angiography in the non-invasive evaluation of significant coronary artery disease
Eur Heart J 2010
29
Chapter 3 Diagnostic performance of non-invasive multidetector computed tomography coronary angiography to detect coronary artery disease using different endpoints: detection of significant stenosis versus detection of atherosclerosis
Eur Heart J 2011
45
Chapter 4 Evaluation of stents and grafts EuroIntervention 2010
63
Chapter 5 Diagnostic accuracy of 320-row multidetector computed
tomography coronary angiography to noninvasively assess in-stent restenosis
Invest Radiol 2010
79
Chapter 6 Diagnostic performance of 320-slice multidetector computed tomography coronary angiography in patients after coronary artery bypass grafting
Eur Radiol 2011
97
Chapter 7 Performance and efficacy of 320-row computed tomography coronary angiography in patients presenting with acute chest pain:
results from a clinical registry Int J Cardiovasc Imaging 2011
117
Table of contents
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