Fluid loading responsiveness
Geerts, B.
Citation
Geerts, B. (2011, May 25). Fluid loading responsiveness.
Retrieved from https://hdl.handle.net/1887/17663 Version: Corrected Publisher’s Version License:
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version (if applicable).
Aan Jo en Frederike
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Fluid loading responsiveness
PROEFSCHRIFT
ter verkrijging van de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof. mr. P.F. van der Heijden,
volgens besluit van het College voor Promoties te verdedigen op woensdag 25 mei 2011
klokke 13.45 uur
door
Bart Franciscus Geerts geboren te Amsterdam
in 1979
4)
(5 Promotiecommissie
Promotor: Prof. dr. L.P.H.J. Aarts Co-promotor: Dr. J.R.C. Jansen
Overige leden: Prof. dr. A.B.J. Groeneveld (Vrije Universiteit Amsterdam) Prof. dr. W. Buhre (Universiteit Utrecht)
Prof. dr. A. Dahan
6)
This study was funded by institutional funds of the departments of intensive care and anaesthesiology of the Leiden University Medical Centre.
Copyright © B.F. Geerts, Amsterdam, The Netherlands Cover: Kanagawa Oki Nami Uraby by Katsushika Hokusai 1831 Design: Boulogne Jonkers Vormgeving, Zoetermeer
Printed by Schulten, Zoetermeer ISBN: 978-90-9026085-3 Typeset in Scala
The printing of this thesis was supported by the department of Anaesthesiology of the LUMC and the Centre for Human Drug Research.
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Index
Introduction 9
Section 1
Accuracy of the measurement of cardiac output and stroke volume variation 18 Chapter 1 – Methods in pharmacology: measurement of cardiac output 19 Chapter 2 – Performance of three minimally invasive cardiac output
monitoring systems 45
Chapter 3 – A comparison of stroke volume variation measured by the
LiDCOPLUS and FloTrac-Vigileo 61
Section 2
Hemodynamic management 72
Chapter 4 – Hemodynamic assessment in Dutch intensive care units 73 Chapter 5 – Fluid loading responsiveness: what parameter can we use? 89 Chapter 6 – Comprehensive review: Is it better to use Trendelenburg
or passive leg raising in the initial treatment of hypovolaemia? 103
Section 3
Mean systemic filling pressure 116
Chapter 7 – Partitioning the resistances along the vascular tree: effects of
dobutamine and hypovolemia in piglets with an intact circulation 117 Chapter 8 – Assessment of venous return curve and mean systemic
filling pressure in postoperative cardiac surgery patients 133 Chapter 9 – Is arm occlusion pressure a predictor of fluid responsiveness? 149
Section 4
Challenges and fluid loading responsiveness 158
Chapter 10 – Predicting cardiac output responses to passive leg raising by a PEEP-induced increase in central venous pressure, in
cardiac surgery patients 159
Chapter 11 – Vincent and Weil’s fluid challenge: revisited and revised 171 Chapter 12 – Pulse contour cardiac output and passive leg raising to
assess fluid loading responsiveness in cardiac-surgery patients 183 Chapter 13 – The Respiratory Systolic Variation Test to predict fluid
loading responsiveness 195
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Section 5
Discussion and conclusions 202
Chapter 14 – Discussion; fluid loading responsiveness and how can we use it? 203
Chapter 15 – Summary 213
Chapter 16 – Samenvatting 221
List of abbreviations 230
Curriculum vitae 234
Dankwoord 235
Publications 236
