Citation
Spilt, A. (2006, March 9). Changes in total cerebral blood flow and morphology in aging.
Retrieved from https://hdl.handle.net/1887/4342
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Changes in Total Cerebral Blood Flow
and M orphology in Aging
PRO EFSCHRIFT
TER VERKRIJG ING VAN
DE G RAAD VAN DO CTO R AAN DE UNIVERSITEIT LEIDEN
O P G EZAG VAN DE RECTO R M AG NIFICUS DR. D. D. BREIM ER,
HO O G LERAAR IN DE FACULTEIT DER W ISKUNDE EN NATUURW ETENSCHAPPEN
EN DIE DER G ENEESKUNDE
VO LG ENS HET BESLUIT VAN HET CO LLEG E VO O R PRO M O TIES
TE VERDEDIG EN O P DO NDERDAG 9 M AART 2006
KLO KKE 16.15 UUR
DO O R
AART SPILT
G EBO REN TE NAARDEN
Contents
Introduction 9
Reproducibility of total cerebral blood fl ow m easurem ents
using phase contrast m agnetic resonance im aging 15
Autom atic m odel-based contour detection and blood fl ow quantifi cation in sm all vessels with velocity encoded
m agnetic resonance im aging 27
M R assessm ent of cerebral vascular response: A com parison
of two m ethods 45
Nitric oxide m ediates hypoxia-induced cerebral vasodilation
in hum ans 57
Basal cerebral blood fl ow is dependent on the nitric oxide
pathway in elderly but not in young healthy m en 69
Cerebral hem odynam ics and white m atter hyperintensities in
CADASIL 77
Age-related changes in norm al-appearing brain tissue and white m atter hyperintensities: m ore of the sam e or som ething
else? 87
Not all age-related white m atter hyperintensities are the
sam e, a m agnetization transfer im aging study 97
Late-onset dem entia: Total cerebral blood fl ow 109
Sum m ary and conclusions 121
References 127
Sam envatting 145
