Citation
Doekhie, F. S. (2009, September 16). Dissemination and clinical impact of minimal metastatic disease in gastrointestinal cancer. Retrieved from https://hdl.handle.net/1887/13980
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License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
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Dissemination and clinical impact of minimal metastatic disease
in gastrointestinal cancer
Cover design: Fania Doekhie en Klaas van der Ham
Gedicht: coupletten uit ‘Wan bon’ van Dobru (Robin Ravales) vertaald door Edgar Cairo.
Uit de bundel: Spiegel van de Surinaamse poezie: van de oude liedkunst tot de jongste dichters. Meulenhoff Amsterdam eerste druk, 1995. Samenstelling: Michiel van Kempen, met medewerking van Jan Bongers.
Dissemination and clinical impact of minimal metastatic disease in gastrointestinal cancer
© F.S. Doekhie 2009 ISBN 978-90-5335-204-5
Printed by Ridderprint Ridderkerk, The Netherlands
Publication of this thesis was financially supported by the Dutch Cancer Society, AstraZeneca BV, Novartis Oncology BV, Greiner Bio-One BV, Roche Nederland BV and Pfizer BV
Dissemination and clinical impact of minimal metastatic disease
in gastrointestinal cancer
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof. mr. P.F. van der Heijden,
volgens besluit van het College voor Promoties te verdedigen op woensdag 16 september 2009
klokke 11.15 uur
door
Fania Shahanaaz Doekhie geboren te Nickerie in Suriname
Overige leden: Prof. dr. H.J. Tanke Prof. dr. H. Morreau Prof. dr. J.W.R. Nortier Dr. H. Putter
Dr. G.J. Liefers
The work in this thesis was financed by the Dutch Cancer Society (project number 2000-2211) and supported in part by the Nijbakker-Morra Foundation, the European Community’s Sixth Framework program (DISMAL project, LSHC- CT-2005-018911) and Applied Imaging, a Genetix company
Eén boom zovele bladeren
één boom
Eén rivier zovele kreken alle op weg naar één zee
Eén hoofd zovele gedachten gedachten om één soort heil
Aan mijn ouders, Ajoeb en Helene
CONTENTS
Chapter 1 General introduction and outline of the thesis 9
Chapter 2 Clinical relevance of occult tumor cells in lymph nodes from gastric cancer patients Am J Surg Pathol 2005;29:1135-1144
29
Chapter 3 Prognostic relevance of occult tumor cells in lymph nodes in colorectal cancer
Eur J Surg Oncol 2006;32:253-258
49
Chapter 4 Automated analysis of multiple sections for the detection of occult cells in lymph nodes Clin Cancer Res 2003;9:4826-4834
61
Chapter 5 Detailed examination of lymph nodes improves prognostication in colorectal cancer Int J Cancer 2009; in press
77
Chapter 6 The feasibility and reliability of sentinel node mapping in colorectal cancer
Eur J Surg Oncol 2005;31:854-862
93
Chapter 7 Disseminated tumor cells in bone marrow of patients with colorectal liver metastases predict survival
107
Chapter 8 Sialyl Lewis X expression and lymphatic microvessel density in primary tumors of node-negative colorectal cancer patients predict disease recurrence
Cancer Microenviron 2008;1:141-151
121
Chapter 9 Summary and general discussion 139
Chapter 10 Nederlandse samenvatting 155
List of abbreviations 167
List of publications 169
Curriculum Vitae 171
Nawoord 173
