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VU Research Portal

More than a synuclein story

Moors, T.E.

2020

document version

Publisher's PDF, also known as Version of record

Link to publication in VU Research Portal

citation for published version (APA)

Moors, T. E. (2020). More than a synuclein story: Dissecting determinants for alpha-synuclein aggregation and

degradation in the Parkinson’s disease brain.

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Contents

Chapter 1: Introduction

o 1.1: Protein aggregation in the pathology of Parkinson’s disease and

related disorders: aSyn as ‘pathological Parkinson protein’

o 1.2: Converging evidence for dysfunctional protein degradation in

Parkinson’s disease

p. 13

p. 27

Chapter 2: Therapeutic potential of autophagy-enhancing agents in

Parkinson’s disease

p. 47

Chapter 3: Multi-platform quantitation of alpha-synuclein brain variants

reveals disease-specific biochemical profiles of synucleinopathies

p. 77

Chapter 4: Characterization of brain lysosomal activities in GBA-related

and sporadic Parkinson's disease and dementia with Lewy bodies

p. 115

Chapter 5: Path mediation analysis reveals GBA impacts Lewy body

disease status by increasing α-synuclein levels

p. 143

Chapter 6: A multitude of morphologies containing alpha-synuclein

variants in brain tissue with different synucleinopathies

p. 173

Chapter 7: Subcellular orchestration of a-synuclein variants in Parkinson’s

disease brains revealed by 3D multicolor STED microscopy

p. 201

Chapter 8: TFEB accumulates at the Golgi network in neurons with

alpha-synuclein cytopathology in GBA-related and sporadic Parkinson’s disease

and dementia with Lewy bodies

p. 255

Chapter 9: Summary and general discussion

p. 281

Nederlandse samenvatting

p. 313

Dankwoord/Acknowledgements

p. 321

List of publications

p. 327

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