Mesenchymal stem cells in skeletal muscle regeneration
Garza-Rodea, A.S. de la
Citation
Garza-Rodea, A. S. de la. (2011, September 28). Mesenchymal stem cells in skeletal muscle regeneration. Retrieved from
https://hdl.handle.net/1887/17877
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
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Mesenchymal Stem Cells in Skeletal Muscle Regeneration
Anabel S. de la Garza-Rodea
Mesenchymal stem cells in skeletal muscle regeneration Thesis, Leiden, the Netherlands
© Anabel S. de la Garza-Rodea, 2011 ISBN: 978-90-8891-323-5
Cover design: Jorge Fiebrich Layout: Tiny Wouters
Printed by: Proefschriftmaken.nl, Oisterwijk
Mesenchymal Stem Cells in Skeletal Muscle Regeneration
PROEFSCHRIFT
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van Rector Magnificus prof.mr. P.F. van der Heijden,, volgens besluit van het College voor Promoties,
te verdedigen op woensdag 28 september 2011, klokke 10.00 uur
door
Anabel Sofía de la Garza Rodea geboren te Mexico stad
in 1979
Promotor:
Prof. dr. D. Valerio
Copromotores:
Dr. S. Knaän-Shanzer Dr. A.A.F. de Vries
Beoordelingscommissie:
Prof. dr. R.C. Hoeben
Prof. dr. C.A. van Blitterswijk (Universiteit Twente) Prof. dr. J.J.G.M. Verschuuren
The studies presented in this thesis were performed at the Leiden University Medical Center at the Department of Molecular Cell Biology, Leiden, the Netherlands. The research was possible by a PhD grant from the Universidad Autónoma de Nuevo León, Monterrey, Mexico, is gratefully acknowledged.
The printing of this thesis was financially supported by Harlan Laboratories and mainly by Javier de la Garza Aguilar, MD.
Table of contents
Chapter 1 General introduction 7
Chapter 2 Long-term contribution of human bone marrow mesenchymal 65 stromal cells to skeletal muscle regeneration in mice
Chapter 3 Myogenic properties of human mesenchymal stem cells 89 derived from three different sources
Chapter 4 Pressure ulcers: description of a new model and the use of mesenchymal stem cells for repair 123
Chapter 5 Anomer-equilibrated streptozotocin solution for the 149 Induction: of experimental diabetes in mice (mus musculus) Chapter 6 Regeneration of human muscle in a mouse model 163
Chapter 7 Exploitation of herpesvirus immune evasion strategies 187 to generate non-immunogenic human mesenchymal
stem cells for use in regenerative medicine
Chapter 8 General discussion 213
Summary 221
Samenvatting 227
Acknowledgments 235
List of publications 239
Curriculum Vitae 243
