Cover Page The handle http://hdl.handle.net/1887/43800

As described in the previous paragraphs, the DNA damage-mediated posttranslational modifications of chromatin and chromatin-associated proteins are crucial for the efficient

No parts of this thesis may be reprinted, reproduced or utilised in any form or by electronic, mechanical, or other means, now known or hereafter devised, includ- ing photocopying

As described in the previous paragraphs, the DNA damage-mediated posttranslational modifications of chromatin and chromatin-associated proteins are crucial for the efficient

To identify novel chromatin regulators that are involved in the response to DSBs, we performed a siRNA screen monitoring the early and late response to DSBs by determining

In contrast, knockdown of CENP-S or CENP-X, similar to that of RSF1 or XRCC4 (Figs. 3D and 5C), significantly reduced the levels of GFP-positive EJ5-GFP cells (Fig. 5C),

To investigate whether SUMOylation of RSF1 plays a role in its recruitment to DSBs, we inflicted DNA damage by laser micro- irradiation in U2OS cells transiently expressing

Interestingly besides NHEJ, RSF1 is also involved in the efficient repair of DSBs via HR (Helfricht et al., 2013) (chapter 3) and the function of RSF1 during both DSB

In addition to the results for eukaryotic MutS, 1D rotational diffusion was also designated as mismatch search mechanism for bacterial MutS based on smFRET experiments