University of Groningen
Machine perfusion of human donor livers with a focus on the biliary tree
Matton, Alix
DOI:
10.33612/diss.102908552
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Publication date: 2019
Link to publication in University of Groningen/UMCG research database
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Matton, A. (2019). Machine perfusion of human donor livers with a focus on the biliary tree. Rijksuniversiteit Groningen. https://doi.org/10.33612/diss.102908552
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Machine Perfusion of Human Donor Livers with a
Focus on the Biliary Tree
Different parts of this PhD project were financially supported by: University Medical Center Groningen
Groningen University Institute of Drug Exploration (GUIDE) Innovatief Actieprogramma Groningen (IAG-3)
Jan Kornelis de Cock Stichting Tekke Huizingafonds
HBO2Therapeutics
The printing of this thesis was financially supported by: University Medical Center Groningen
Research Institute GUIDE
Nederlandse Transplantatie Vereniging Nederlandse Vereniging voor Hepatologie
Author: Alix Petra Margarita Matton Cover: enviromantic
Printed by: Ridderprint B.V. ISBN: 978-94-034-2215-2
Copyright © 2019 Alix Petra Margarita Matton. All rights reserved. No part of
Machine Perfusion of Human Donor Livers
with a Focus on the Biliary Tree
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. C. Wijmenga en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op woensdag 11 december 2019 om 11.00 uur
door
Alix Petra Margarita Matton
geboren op 28 november 1991 te Leuven, België
Promotores
Prof. dr. R.J. Porte Prof. dr. J.A. Lisman
Beoordelingscommissie
Prof. dr. U.H. Beuers Prof. dr. H.G.D. Leuvenink Prof. dr. J.M. Klaase
Paranimfen
Dr. L.C. Burlage Drs. S. Karangwa
Table of Contents
Chapter 1 General Introduction and Aims of this Thesis 7
Chapter 2 Opportunities for Scientific Expansion of the Deceased 13 Donor Pool in Liver Transplantation
Liver Transplantation. 2014; 20 Suppl 2:S5.
Chapter 3 Ex Situ Normothermic Machine Perfusion of Donor Livers 25
Journal of Visualized Experiments. 2015; 26:e52688.
Chapter 4 Normothermic Machine Perfusion of Donor Livers Without 43 the Need for Human Blood Products
Liver Transplantation. 2018; 24:528-538.
Chapter 5 Pretransplant Sequential Hypo- and Normothermic Machine 65
Perfusion of Suboptimal Livers Donated After Circulatory Death Using a Hemoglobin-based Oxygen Carrier Perfusion Solution
American Journal of Transplantation 2019;19:1202-1211.
Chapter 6 Biliary Bicarbonate, pH and Glucose Are Suitable Biomarkers 87
of Biliary Viability During Ex Situ Normothermic Machine Perfusion of Human Donor Livers
Transplantation. 2019; 103:1405-1413.
Chapter 7 Early Prediction of Graft Viability by Cell-free MicroRNAs 111 During Ex Vivo Normothermic Machine Perfusion of
Human Liver Grafts
In preparation for submission
Chapter 8 The Influence of Flushing and Cold Storage Preservation 131 Solution on Biliary Injury Prior to Liver Transplantation
In preparation for submission
Chapter 9 Peribiliary Glands are Key in Regeneration of the Human 147 Biliary Epithelium After Severe Bile Duct Injury
Hepatology. 2019; 69:1719-1734
Chapter 10 Summary, General Discussion & Future Perspectives 171
Chapter 11 Dutch Summary | Nederlandse samenvatting 182
List of Publications 189
List of Contributing Authors 191
