University of Groningen
Dissecting the temporal dynamics of eukaryotic metabolism in single cells Takhaveev, Vakil
DOI:
10.33612/diss.119793412
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Publication date: 2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Takhaveev, V. (2020). Dissecting the temporal dynamics of eukaryotic metabolism in single cells. University of Groningen. https://doi.org/10.33612/diss.119793412
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Propositions
1. No sensible interpretation of cell growth can be made without a knowledge of the overall pattern of protein synthesis. – “The Biology of the Cell Cycle”, J.M. Mitchison
2. The synthesis of different biomass components, i.e. proteins, lipids and polysaccharides, is, to some extent, temporally segregated. – Chapter 2, this thesis
3. The existence of the decoupling among fundamental processes underlying cell growth should
make the usage of the term “cell growth” more careful since it does not stand for one process only. – Chapter 2, this thesis
4. Many of the current single-cell-level tools probing metabolism are still at the
proof-of-concept level, which means that thorough in vivo validation is necessary before these tools can be routinely applied for actual research. – from Chapter 1, inspired by Chapter 3, this
thesis
5. The engineered RNA-based biosensor for glycolytic flux makes it possible to read the
functional output of the principal metabolic pathway in real time in single cells. – Chapter 5,
inspired by Chapter 4, this thesis
6. The pleasure of analysing large amounts of scattered data and finding regularities in them can be compared only to the entertainment of working with extraordinary and intelligent people. I was lucky to have both.
7. I am sufficiently proud of my knowing something to be modest about my not knowing all. – «Lolita», V. Nabokov
